The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus
Table 5
Markers suggestive of association with skin-related clinical criteria. “Conditioned on …” = results from conditional logistic regression performed conditioning on the indicated SNP, MA: minor allele, “Case” and “Cont”: allele frequency of the minor allele in cases and controls respectively, OR: odds ratio, 95% CI = 95% confidence interval of the odds ratio, : value, AA: African-American ancestry, EA: European ancestry, Female −: female subjects lacking the indicated skin phenotype, Female +: female subjects with the indicated skin phenotype, Male −: males lacking the indicated skin phenotype, Male +: males with the indicated skin phenotype, Female ORs: odds ratio comparing female patients with and without the indicated skin phenotype, and Male OR: odds ratio comparing male patients with and without the indicated skin phenotype.
(a) AA female malar rash.
SNP
MA
OR (95% CI)
Conditioned on rs4879541
OR
rs4609281
C
1.35 (1.03–1.78)
.030
1.28
.091
rs11792285
A
0.60 (0.37–0.98)
.043
0.92
.81
rs4879541
G
0.58 (0.39–0.85)
.0061
—
—
rs7469146
A
0.57 (0.36–0.89)
.015
0.84
.66
rs10812611
A
0.57 (0.36–0.89)
.014
0.80
.56
(b) EA female discoid rash.
SNP
MA
OR (95% CI)
Conditioned on rs2814707
OR
rs4609281
C
1.47 (1.08–1.98)
.013
1.04
.91
rs2814707
A
1.55 (1.13–2.12)
.0063
—
—
rs12686452
G
0.65 (0.45–0.94)
.023
.73
.11
(c) Evidence for opposing associations with skin phenotypes in female and male subjects.
