Research Article

High Prevalence of Alpha- and Beta-Thalassemia in the Kadazandusuns in East Malaysia: Challenges in Providing Effective Health Care for an Indigenous Group

Table 1

Frequency of 𝛼 - and 𝛽 -thalassemia defects in the Kadazandusuns in Sabah.

Deletional 𝛼 -thalassemiaNondeletional 𝛼 -thalassemia 𝛽 -thalassemia
𝛼 3 . 7 𝛼 4 . 2 - - S E A - - F I L - - T H A I HbCSHbQSFilipino 𝛽 -thalassemia deletion *22 𝛽 -mutations

Kadazandusun42000000160
𝑛 = 1 2 5 (%)(33.6%)(12.8%)

*The 22 𝛽 -thalassemia mutations are CD41/42 (−CTTT), IVS2-654 (C T), CD26 (GAG AAG, HBE), IVS1-5 (G C), −28 (A G), CD43 (GAG TAG), CD27/28 (+C), −29 (A G), CD71/72 (+A), CD17 (AAG TAG), CD19 (AAC AGC), Poly A (AATAAA AATAGA), −88 (C T), Initiation codon (ATG AGG), CAP (+1) (A C), CD8/9 (+G), CD16 (−C), CD35 (−C), IVS2-1 (G A), IVS1-1 (G A), IVS1-1 (G T) and CD15 (TGG TAG).