Research Article
A Comprehensive In Silico Analysis of the Functional and Structural Impact of SNPs in the IGF1R Gene
Table 3
RMSD and total energy of native structure (2jo9) and mutant modeled structures.
| | dbSNP ID | Amino Acid change | RMSD between native and mutant structures | Total energy after minimization (KJ/mol) |
| | rs61740868 | Arg1216Cys | 0,48 | −13343.28 | | rs45526336 | Glu1253Lys | 0,38 | −13887.05 | | rs45512296 | Arg1216His | 0,46 | −13483.34 | | rs45504297 | Leu1211Pro | 0,22 | −13782.33 |
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Total energy of native structure (2jo9) after energy minimization: −13841.67.
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