Mechanism of Catch Force: Tethering of Thick and Thin Filaments by Twitchin

<table>Effect of blebbistatin on force output and on the sensitivity of force to twitchin phosphorylation in permeabilized ABRM. Note that the addition of cAMP after blebbistatin treatment decreased force in pCa5 to nearly that present in relaxing solution (pCa <svg height="8.8500004" id="M41" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
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</svg> 8). <svg height="10.325" id="M42" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.225 10.325" width="11.225" xmlns="http://www.w3.org/2000/svg">
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</svg> = 20 C. Reproduced from [<a href="/journals/bmri/2010/725207/#B98">98</a>] with permission.</table>

BioMed Research International

fig8

Figure 8

Figure 8: Mechanism of Catch Force: Tethering of Thick and Thin Filaments by Twitchin 