Toll-Like Receptor Initiated Host Defense against Toxoplasma gondii

Table 1

Summary of findings in TLR/MyD88 knockout mice.

Mouse strain	Susceptibility	Phenotype	References
MyD 88^−/−	Highly susceptible	Uncontrolled parasite growth; defective IL-12 production; delayed emergence of Th1 response	[16, 17]
IC 𝐸^−/−	Normal resistance	Normal	[18]
TLR 11^−/−	Intermediate resistance	Higher cyst burden; mice are resistant to ileitis during enteric infection	[19, 20]
TLR 2^−/−	Intermediate resistance	Mice are susceptible under high infectious dose conditions	[21]
TLR 4^−/−	Unclear	Absence of TLR4 confers resistance to gut pathology; absence of TLR4 results in increased susceptibility to peroral infection	[22, 23]
TLR 2𝑥4^−/−	Intermediate resistance	Higher cyst burden in the absence of TLR4 and TLR2; decreased intestinal pathology during enteric infection	[20, 24]
TLR 9^−/−	Intermediate resistance	Deceased gut pathology; increased parasite burden	[25]