The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity

<table>IL-2 transcriptional regulation in T cells. Upon T cell activation, CREB is phosphorylated leading to IL-2 transcription. CREM is also phosphorylated upon T cell activation and it will displace pCREB to shut down IL-2 transcription. CaMKIV is upregulated in SLE and it is responsible for phosphorylation of CREM. PP2A is also upregulated in SLE and this phosphatase dephosporylates CREB.</table>

BioMed Research International

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Figure 1

Figure 1: The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity 