Gene Expression Profiling of Placentas Affected by Pre-Eclampsia

Table 3

Regulation of genes in pre-eclamptic placentas compared to controls.

Accession^1	Gene of interest	Fold change	𝑃-value
Antioxidant enzymes
NM_003330.1	thioredoxin reductase 1	−1.57	.025
Eicosanoid metabolism
U63296.1	hydroxyprostaglandin dehydrogenase 15-(NAD^+),	1.48	.027
BC005939.1	prostaglandin D2 synthase 21 kDa (brain)	−1.51	.031
Energy metabolism
AI761561	hexokinase 2	1.59	.045
NM_000230.1	leptin	2.94	.025
AA502643	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein e	−1.65	.005
Inhibin-activin system
NM_002192.1	inhibin, beta A subunit (activin A, activin AB alpha polypeptide)	2.06	.007
Matrix proteins
NM_000494.1	collagen, type XVII, alpha 1	1.50	.039
NM_006487.1	fibulin 1A	−2.49	.009
Transcription factors
AA972711	zinc finger protein 292	−1.37	.024
NM_005121.1	thyroid hormone receptor-associated protein, 240 kDa subunit	−1.32	.012
Vascular factors
NM_000710.1	bradykinin B1 receptor	−1.44	.024
NM_013332.1	hypoxia-inducible protein 2	1.61	.029
Miscellaneous
AI206718	ESTs, Weakly similar to zinc finger protein 339	1.52	.024
AF052169.1	hypothetical protein BC013764	−1.46	.033
AF007149.1	hypothetical protein LOC257407	−1.40	.035
AK025495.1	KIAA0790 protein	1.56	.041
AK027231.1	KIAA1102 protein	1.54	.003
AB033025.1	KIAA1199 protein	1.59	.040
NM_004844.1	SH3-domain binding protein 5 (BTK-associated), (signal transduction)	1.58	.030
AF016535.1	ATP-binding cassette, sub-family B (MDR/TAP), member 1, (transporter activity)	1.45	.037

¹Genbank accession number.