Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC
Figure 3
Simplified model for the effects of EGFR/ErbB1 signaling on MSC osteogenic differentiation. Weak and temporal stimulation of EGFR/ErbB1 exerts anti-osteogenic effects, whereas strong and sustained stimulation of EGFR/ErbB1 exerts pro-osteogenic effects on MSC.