Review Article

Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC

Figure 6

The roles of soluble and tethered EGFR/ErbB1 ligands on MSC physiology. Soluble EGFR/ErbB1 ligands (EGF, HB-EGF, TGF- 𝛼 ) enhance paracrine secretions, proliferation, and migration of MSCs. Tethered EGF or EGF-like repeats within tenascin or laminin augment osteogenic differentiation of MSCs, in addition to cytoprotective, motogenic, and mitogenic effects on MSCs.
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