Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC
Figure 6
The roles of soluble and tethered EGFR/ErbB1 ligands on MSC physiology. Soluble EGFR/ErbB1 ligands (EGF, HB-EGF, TGF-) enhance paracrine secretions, proliferation, and migration of MSCs. Tethered EGF or EGF-like repeats within tenascin or laminin augment osteogenic differentiation of MSCs, in addition to cytoprotective, motogenic, and mitogenic effects on MSCs.