[Retracted] Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium

Figure 1

Gelsolin expression in choroid plexus epithelial cells. (a) Antimegalin immunoprecipitation of rat choroid plexus cell extracts, followed by blotting with respective antibodies, revealed an association between megalin, endogenous gelsolin, the exogenously added secreted gelsolin form, and the exogenously added A𝛽. Immunoprecipitation with nonspecific serum showed no unspecific A𝛽 association. Binding of gelsolin with exogenously added A𝛽 was also observed. Representative blots are shown (𝑛=4). (b) Megalin colocalized with gelsolin and exogenously added A𝛽 in choroid plexus cultures. Confocal images also show gelsolin colocalization with A𝛽. Scalebars=10 𝜇m. IP: Immunoprecipitation; NRS: normal rabbit serum.

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