Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients

Figure 3

Serum IFN-𝛼 activity in African-American SLE patients stratified by rs3813065 genotype and presence or absence of the anti-Ro positive/anti-Sm positive serologic phenotype. Serum IFN-𝛼 is represented in relative units on the 𝑌-axis, as described in Methods. “Anti-Ro+/Anti-Sm+” indicates SLE patients who have positive tests for both anti-Ro and anti-Sm, and “All others” indicates all of the other SLE patients who lack one or both of these autoantibodies. Line drawn at the median and error bars show the interquartile range. 𝑃 value by Mann-Whitney 𝑈 test for a difference between subjects with CT genotype with versus without the anti-Ro+/anti-Sm+ serology.