Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients

Table 2

Association of the rs3813065 C allele with anti-Ro and anti-Sm positive patients in each ancestral background.

	Antibody profile	MAF	OR (C allele)	95 CI	𝑃 value
African-american	Ro+ Sm+ SLE	0.245	2.24	1.34–3.73	2.0 × 10^−3
	All other SLE	0.395
Hispanic-american	Ro+ Sm+ SLE	0.119	3.30	0.67–16.25	.14
	All other SLE	0.248
European-american	Ro+ Sm+ SLE	0.115	2.21	0.28–17.67	.45
	All other SLE	0.160
Meta-analysis	Ro+ Sm+ SLE versus all other SLE	—	2.26	1.43–3.55	5.0 × 10^−4

MAF: minor allele frequency, OR: odds ratio for association of the C allele with Ro+Sm+ patients as compared to all other SLE patients, and 95 CI = 95% confidence interval of the odds ratio.