Table 1: Effect of PPAR modulation on the outcome of parasitic infections.

ParasiteAnimal modelTreatmentPPAR statusOutcomeReference

Increase in parasite load

Leishmania majorMurine cutaneous leishmaniasisGene knockoutPPAR 𝛾 / macrophagesDecreased footpad swelling[41]
Leishmania donovaniMurine visceral leishmaniasisCurcuminPPAR 𝛾 PPARα Increased parasite load[42]

Decrease in host tissue damage

Schistosoma japonicumMurine hepatic fibrosisRosiglitazone (Praziquantel)PPAR 𝛾 Decreased fibrosis[60]
Plasmodium bergheiMurine cerebral malariaRosiglitazoneNot statedIncreased survival[57]
Plasmodium chabaudiMurine malariaRosiglitazoneNot statedDecreased parasitemia[57]