Peroxisome Proliferator-Activated Receptor (PPAR): Balance for Survival in Parasitic Infections

Table 1

Effect of PPAR modulation on the outcome of parasitic infections.

Parasite	Animal model	Treatment	PPAR status	Outcome	Reference
Increase in parasite load
Leishmania major	Murine cutaneous leishmaniasis	Gene knockout	PPAR𝛾^−/− macrophages	Decreased footpad swelling	[41]
Leishmania donovani	Murine visceral leishmaniasis	Curcumin	PPAR𝛾 ↑ PPARα ↑	Increased parasite load	[42]
Decrease in host tissue damage
Schistosoma japonicum	Murine hepatic fibrosis	Rosiglitazone (Praziquantel)	PPAR𝛾↑	Decreased fibrosis	[60]
Plasmodium berghei	Murine cerebral malaria	Rosiglitazone	Not stated	Increased survival	[57]
Plasmodium chabaudi	Murine malaria	Rosiglitazone	Not stated	Decreased parasitemia	[57]