Review Article

IL-10 and TNFα Genotypes in SLE

Table 1

Main functional IL-10 and TNF 𝛼 SNPs involved in SLE.

IL-10TNF 𝛼

Functional polymorphism 1 0 8 2 A/G 3 0 8 G/A
rs number18008961800629
High producer allele 1 0 8 2 G* 3 0 8 A*
Population frequency of high producer allele ( 1 )
 North/Centre European and  North American [32, 40, 44, 46]0.43–0.520.11–0.17
 South European [30, 36, 39, 45]0.29–0.400.12–0.14
 South American [31, 37, 38, 42]0.29–0.350.08–0.03
 Asian [29, 34, 35, 41, 43]0.04–0.060.10–0.14

( 1 ) Ranges of allele frequency in healthy population.