IL-10 and TNFα Genotypes in SLE

Table 2

Summary of association studies of IL-10 promoter polymorphisms with SLE.

Reference	Population	SLE/controls	Polymorphisms	Associations
Rosado et al. (2008) [59]	Spanish	116/51	IL10G, IL10R; −1082/−819/−592	No association of microsatellites; Increased GCC in SLE
Guarnizo-Zuccardi et al. (2007) [31]	Colombian	120/102	−1082/−819/−592	No association
Chen et al. (2006) [60]	Taiwanese	237/304	IL10G	Increased G9 and decreased G8 in SLE. G13 associated with anticardiolipin IgM antibodies and G8 with neurologic affectation.
Sung et al. (2006) [61]	Korean	350/330	−592	No association with susceptibility; −592C associated with SLE activity
Nath et al. (2005) [62]	Meta-analysis	2391/3483	IL10G/IL10R; −1082/−819/−592	Increased G11 in whole population; Increased −1082G in Asian populations
Khoa et al. (2005) [63]	Vietnamese	64/57	−1082	Increased −1082G in SLE
Chong et al. (2004) [29]	Chinese	550/689; 554/708	IL10G, IL10R; −1082/−819/−592	Increased G4 in SLE; Increased −592CC in SLE
Schotte et al. (2004) [65]	German	210/158	IL10G, IL10R	No association with susceptibility; R2-G14 associated with anti-Sm antibodies
Suarez et al. (2004) [45]	Spanish	248/343	−1082,−819,−592	No association with susceptibility. Association of −1082G with discoid lesions
Dijstelbloem et al. (2002) [64]	Caucasian	180/163	−1082	No association
D’Alfonso et al. (2002) [66]	Italian	217/173	−1082/−851/−592; IL10G	Association of IL10G “long alleles” with SLE
D’Alfonso et al. (2000) [30]	Italian	159/164	IL10G, IL10R	Increased G11 and decreased G9 in SLE
van der Linden et al. (2000) [67]	Mixed	44/125	−1082/−851/−592	No association
Alarcon-Riquelme et al. (1999) [68]	Mexican	330/368	IL10G	No association
Rood et al. (1999) [28]	Dutch	92/162	−1082/−819/−592	Increased ATA in neuropsychiatric SLE
Crawley et al. (1999) [69]	Anglo-saxon	120/274	−1082/−819/−592	No association
Mok et al. (1998) [34]	Chinese	83/88	−1082/−819/−592	No association with susceptibility; Increased ATA in renal disease
Mehrian et al. (1998) [70]	Mexican-American	158/220	IL10G	Increased G10 and decreased G9 in SLE
Eskdale et al. (1997) [71]	Anglo-Saxon	56/102	IL-10G, IL-10R	Increased G13 and decreased G9 in SLE
Lazarus et al. (1997) [27]	Anglo-Saxon	76/199	−1082/−819/−592	GCC associated with anti-SSa