The Lipid Moiety of Haemozoin (Malaria Pigment) and P. falciparum Parasitised Red Blood Cells Bind Synthetic and Native Endothelin-1

Figure 3

Failure of ET-1 receptor antagonists to inhibit ET-1 removal by pRBC ET-1 (5 fmol/mL) was incubated for 24 hours with normal RBC or pRBC (D10) in medium only (empty bars) or in the presence of JKC302, an ET-A receptor antagonist (striped bars) or BQ788, an ET-B receptor antagonist (dotted bars), or in the presence of JKC302 and BQ788 simultaneously. Data are expressed as % of ET-1 recovered in the supernatants and represent the mean ± SD of three different experiments.