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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 860160, 7 pages
Prime-Boost Vaccination Using Chemokine-Fused gp120 DNA and HIV Envelope Peptides Activates Both Immediate and Long-Term Memory Cellular Responses in Rhesus Macaques
1Department of Lymphoma and Myeloma, M. D. Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
2Center for Cancer Immunology Research, M. D. Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
3Department of Veterinary Sciences, M. D. Anderson Cancer Center, The University of Texas, Bastrop, TX 78602, USA
4Department of Immunology, M. D. Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
Received 21 November 2009; Accepted 2 March 2010
Academic Editor: Hanchun Yang
Copyright © 2010 Hong Qin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. T. Catanzaro, R. A. Koup, M. Roederer, et al., “Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector,” Journal of Infectious Diseases, vol. 194, no. 12, pp. 1638–1649, 2006.
- M. J. Cayabyab, A.-H. Hovav, T. Hsu, et al., “Generation of T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env,” Journal of Virology, vol. 80, no. 4, pp. 1645–1652, 2006.
- A. Biragyn, K. Tani, M. C. Grimm, S. Weeks, and L. W. Kwak, “Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity,” Nature Biotechnology, vol. 17, no. 3, pp. 253–258, 1999.
- A. Biragyn, P. A. Ruffini, C. A. Leifer, et al., “Toll-like receptor 4-dependent activation of dendritic cells by -defensin 2,” Science, vol. 298, no. 5595, pp. 1025–1029, 2002.
- A. Biragyn, M. Surenhu, D. Yang, et al., “Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens,” Journal of Immunology, vol. 167, no. 11, pp. 6644–6653, 2001.
- A. Biragyn, I. M. Belyakov, Y.-H. Chow, D. S. Dimitrov, J. A. Berzofsky, and L. W. Kwak, “DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses,” Blood, vol. 100, no. 4, pp. 1153–1159, 2002.
- P. N. Nehete, S. J. Schapiro, P. C. Johnson, K. K. Murthy, W. C. Satterfield, and K. J. Sastry, “A synthetic peptide from the first conserved region in the envelope protein gp160 is a strong T-cell epitope in HIV-infected chimpanzees and humans,” Viral Immunology, vol. 11, no. 3, pp. 147–158, 1998.
- P. N. Nehete, W. C. Satterfield, C. M. Matherne, R. B. Arlinghaus, and K. J. Sastry, “Induction of human immunodeficiency virus-specific T cell responses in rhesus monkeys by synthetic peptides from gp160,” AIDS Research and Human Retroviruses, vol. 9, no. 3, pp. 235–240, 1993.
- P. N. Nehete, B. P. Nehete, P. Manuri, L. Hill, J. L. Palmer, and K. J. Sastry, “Protection by dendritic cells-based HIV synthetic peptide cocktail vaccine: preclinical studies in the SHIV-rhesus model,” Vaccine, vol. 23, no. 17-18, pp. 2154–2159, 2005.
- D. Lomada, R. Gambhira, P. N. Nehete, et al., “A two-codon mutant of cholera toxin lacking ADP-ribosylating activity functions as an effective adjuvant for eliciting mucosal and systemic cellular immune responses to peptide antigens,” Vaccine, vol. 23, no. 4, pp. 555–565, 2004.
- G. T. Mercier, P. N. Nehete, M. F. Passeri, et al., “Oral immunization of rhesus macaques with adenoviral HIV vaccines using enteric-coated capsules,” Vaccine, vol. 25, no. 52, pp. 8687–8701, 2007.
- J. Baig, D. B. Levy, P. F. McKay, et al., “Elicitation of simian immunodeficiency virus-specific cytotoxic T lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination,” Journal of Virology, vol. 76, no. 22, pp. 11484–11490, 2002.
- R. S. Veazey, M. Rosenzweig, D. E. Shvetz, et al., “Characterization of gut-associated lymphoid tissue (GALT) of normal rhesus macaques,” Clinical Immunology and Immunopathology, vol. 82, no. 3, pp. 230–242, 1997.
- M.-C. Gauduin, A. Kaur, S. Ahmad, T. Yilma, J. D. Lifson, and R. P. Johnson, “Optimization of intracellular cytokine staining for the quantitation of antigen-specific T cell responses in rhesus macaques,” Journal of Immunological Methods, vol. 288, no. 1-2, pp. 61–79, 2004.
- L. Musey, J. Hughes, T. Schacker, T. Shea, L. Corey, and M. J. Mcelrath, “Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection,” New England Journal of Medicine, vol. 337, no. 18, pp. 1267–1274, 1997.
- J. E. Schmitz, M. J. Kuroda, S. Santra, et al., “Control of viremia in simian immunodeficiency virus infection by lymphocytes,” Science, vol. 283, no. 5403, pp. 857–860, 1999.
- H. Qin, S.C. Cha, S. S. Neelapu, et al., “Vaccine site inflammation potentiates idiotype DNA vaccine-induced therapeutic T cell-, and not B cell-, dependent antilymphoma immunity,” Blood, vol. 114, no. 19, pp. 4142–4149, 2009.
- R. Schiavo, D. Baatar, P. Olkhanud, et al., “Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific T-cell responses,” Blood, vol. 107, no. 12, pp. 4597–4605, 2006.
- T. Hirbod and K. Broliden, “Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women,” Journal of Internal Medicine, vol. 262, no. 1, pp. 44–58, 2007.
- T. Kinashi, N. Harada, and E. Severinson, “Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II,” Nature, vol. 324, no. 6092, pp. 70–73, 1986.
- J. Gauldie, C. Richards, D. Harnish, P. Lansdorp, and H. Baumann, “Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 84, no. 20, pp. 7251–7255, 1987.
- T. Andus, T. Geiger, and T. Hirano, “Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-2) regulates -fibrinogen and albumin mRNA levels in Fao-9 cells,” FEBS Letters, vol. 221, no. 1, pp. 18–22, 1987.
- Y. Shabo, J. Lotem, M. Rubinstein, et al., “The myeloid blood cell differentiation—inducing protein MGI-2A is interleukin-6,” Blood, vol. 72, no. 6, pp. 2070–2073, 1988.
- N. A. Doria-Rose, C. Ohlen, P. Polacino, et al., “Multigene DNA priming-boosting vaccines protect macaques from acute -T-cell depletion after simian-human immunodeficiency virus SHIV89.6P mucosal challenge,” Journal of Virology, vol. 77, no. 21, pp. 11563–11577, 2003.