Bioinformatics in New Generation Flavivirus Vaccines

Table 1

Summary of flavivirus candidate vaccines based on different vaccine platforms.

Type of vaccine	Virus	Antigen	Comments
Inactivated/killed	JEV	Whole virus	Licenced for human use
	DENV-2	Whole virus	Pre clinical studies in mice and non-human primates
	WNV	E, prM, whole virus	Low immunogenicity, use of adjuvant necessary
Subunit	DENV-2	D III, NS1, E protein	Immunogenicity tested only in mice
	DENV-4	C-M-E-NS1	Immunogenicity tested only in mice
	WNV	D III, E protein, NS1	Low immunogenicity, only tested in mice
	JEV	prM-E	Immunogenicity tested only in mice
DNA	DENV	prM-E, NS1	Low immunogenicity
	JEV	E	Low immunogenicity
	WNV	E, prM, C	Low immunogenicity
Live attenuated	YFV		Licenced for human use
	Mono- and tetravalent DENV		Phase I, and II clinical trials ongoing
	JEV		Phase I and II clinical trials conducted
	WNV
Vectored	WNV	E, prM	Vectors used: MVA, MV, AdV, pox-, alphaviruses