Global Egr1-miRNAs Binding Analysis in PMA-Induced K562 Cells Using ChIP-Seq

Figure 4

Schematic diagram of miRNA related Egr1’s contribution to erythroid/megakaryocytic lineage determination of K562 cells. mir-27a, mir-10a, mir-103-1 and mir-103-2 were found Egr1 binding signals in this study. Based on literature data, when K562 cells were induced by PMA, the expression levels of these miRNAs increased. On the contrary, their expression level were found decreased when K562 cells were induced to erythroid differentiation.