The Receptor for Advanced Glycation End Products (RAGE) and the Lung

Figure 1

Schematic representation of RAGE and the generation of some of its isoforms commonly found in the lung. In addition to its full-length form (mRAGE), RAGE also exists in a soluble form (sRAGE) which lacks the transmembrane and cytosolic domains found in mRAGE. Production of sRAGE isoforms is via either proteolytic cleavage, which gives rise to cleaved RAGE (cRAGE) or alternative splicing at exon 9 resulting in a C-truncated form termed endogenous secretory RAGE (esRAGE).