About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 923193, 14 pages
http://dx.doi.org/10.1155/2010/923193
Review Article

Echinococcus multilocularis and Its Intermediate Host: A Model of Parasite-Host Interplay

1WHO-Collaborating Centre for the Prevention and Treatment of Human Echinococcosis, CHU de Besançon and Université de Franche-Comté, Place Saint Jacques, 25030 Besançon, France
2Institute of Parasitology, University of Bern, Länggasstrasse 122, CH-3012 Bern, Switzerland

Received 21 September 2009; Accepted 7 January 2010

Academic Editor: Jorge Morales-Montor

Copyright © 2010 Dominique Angèle Vuitton and Bruno Gottstein. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [32 citations]

The following is the list of published articles that have cited the current article.

  • Maxi Margos, and Bruno Gottstein, “Gerbu adjuvant modulates the immune response and thus the course of infecti on in C56BL/6 mice immunised with Echinococcus multilocularis rec14-3-3 pro tein,” Parasitology Research, vol. 107, no. 3, pp. 623–629, 2010. View at PublisherView at Google Scholar
  • Barrie Anthony, Jeremy T. Allen, Yuesheng S. Li, and Donald P. McManus, “Hepatic stellate cells and parasite-induced liver fibrosis,” Parasites & Vectors, vol. 3, 2010. View at PublisherView at Google Scholar
  • Tao Li, Jin-Ming Zhao, Yan Zhang, Zu-La Pai, Wei Zhang, Tuxun Tuer-Hongjiang, Lei Bai, Jiang Wu, and Hao Wen, “Suppression of acute rejective response following orthotopic liver transplantation in experimental rats infected with echinococcus multilocularis,” Chinese Medical Journal, vol. 124, no. 18, pp. 2818–2823, 2011. View at PublisherView at Google Scholar
  • Ryo Nakao, Yayoi Kameda, Hirokazu Kouguchi, Jun Matsumoto, Zhisheng Dang, Ayo Yila Simon, Daisuke Torigoe, Nobuya Sasaki, Yuzaburo Oku, Chihiro Sugimoto, Takashi Agui, and Kinpei Yagi, “Identification of genetic loci affecting the establishment and development of Echinococcus multilocularis larvae in mice,” International Journal for Parasitology, vol. 41, no. 11, pp. 1121–1128, 2011. View at PublisherView at Google Scholar
  • Oleg Blagosklonov, Jenny Knapp, Frédéric Grenouillet, Yasuhito Sako, Eric Delabrousse, Marie-Pascale Brientini, Carine Richou, Anne Minello, Anca-Teodora Antonino, Michel Gillet, Akira Ito, Georges André Mantion, Dominique Angèle Vuitton, and Solange Bresson-Hadni, “Should possible recurrence of disease contraindicate liver transplantation in patients with end-stage alveolar echinococcosis? A 20-year follow-up study,” Liver Transplantation, vol. 17, no. 7, pp. 855–865, 2011. View at PublisherView at Google Scholar
  • Alvaro Díaz, Cecilia Casaravilla, Judith E. Allen, Robert B. Sim, and Ana M. Ferreira, “Understanding the laminated layer of larval Echinococcus II: immunology,” Trends in Parasitology, vol. 27, no. 6, pp. 264–273, 2011. View at PublisherView at Google Scholar
  • Peter Kern, Grüner, and Wahlers, “Diagnosis and course of echinococcocal diseases in the transplant setting,” Transplant Infectious Disease, vol. 13, no. 3, pp. 217–221, 2011. View at PublisherView at Google Scholar
  • Manuel Nell, Rainer H. Burgkart, Guntmar Gradl, Rüdiger von Eisenhart-Rothe, Christoph Schaeffeler, Dennis Trappe, Clarissa P. da Costa, Reiner Gradinger, and Chlodwig Kirchhoff, “Primary extrahepatic alveolar echinococcosis of the lumbar spine and the psoas muscle,” Annals of Clinical Microbiology and Antimicrobials, vol. 10, 2011. View at PublisherView at Google Scholar
  • S. Drazilova, J. Kincekova, L'. Bena, M. Zachar, M. Svajdler, P. Zavacky, and P. Jarcuska, “Alveolar echinococcosis in patient after cadaveric kidney transplantation,” Helminthologia, vol. 48, no. 4, pp. 229–236, 2011. View at PublisherView at Google Scholar
  • J.-Y. Shan, W.-Z. Ji, H.-T. Li, T. Tuxun, R.-Y. Lin, and H. Wen, “TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10,” Parasite Immunology, vol. 33, no. 12, pp. 692–696, 2011. View at PublisherView at Google Scholar
  • Martine Piarroux, Renaud Piarroux, Roch Giorgi, Jenny Knapp, Karine Bardonnet, Bertrand Sudre, Jérôme Watelet, Jérôme Dumortier, Alain Gérard, Jean Beytout, Armand Abergel, Georges Mantion, Dominique A. Vuitton, and Solange Bresson-Hadni, “Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: Results of a survey in 387 patients,” Journal of Hepatology, vol. 55, no. 5, pp. 1025–1033, 2011. View at PublisherView at Google Scholar
  • Katrien Pletinckx, Benoit Stijlemans, Vladimir Pavlovic, Regina Laube, Carolin Brandl, Susanne Kneitz, Alain Beschin, Patrick De Baetselier, and Manfred B. Lutz, “Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses,” European Journal of Immunology, vol. 41, no. 12, pp. 3479–3494, 2011. View at PublisherView at Google Scholar
  • Sebastian Pohle, Raoul Ernst, Colin MacKenzie, Martin Spicher, Thomas Romig, Andrew Hemphill, and Stephan Gripp, “Echinococcus multilocularis: The impact of ionizing radiation on metacestod es,” Experimental Parasitology, vol. 127, no. 1, pp. 127–134, 2011. View at PublisherView at Google Scholar
  • Katrien Pletinckx, Anja Döhler, Vladimir Pavlovic, and Manfred B. Lutz, “Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells,” Frontiers in Immunology, vol. 2, 2011. View at PublisherView at Google Scholar
  • Zhisheng Dang, Jinchao Feng, Kinpei Yagi, Chihiro Sugimoto, Wei Li, and Yuzaburo Oku, “Mucosal Adjuvanticity of Fibronectin-Binding Peptide (FBP) Fused with Echinococcus multilocularis Tetraspanin 3: Systemic and Local Antibody Responses,” PLoS Neglected Tropical Diseases, vol. 6, no. 9, 2012. View at PublisherView at Google Scholar
  • S. Dražilová, J. Kinčeková, Ľ. Beňa, M. Zachar, M. Švajdler, A. Königová, M. Janičko, and P. Jarčuška, “Regression of alveolar echinococcosis after chronic viral hepatitis C treatment with pegylated interferon alpha 2a,” Helminthologia, vol. 49, no. 3, pp. 134–138, 2012. View at PublisherView at Google Scholar
  • Zhisheng Dang, Kinpei Yagi, Yuzaburo Oku, Hirokazu Kouguchi, Kiichi Kajino, Jun Matsumoto, Ryo Nakao, Hiroyuki Wakaguri, Atsushi Toyoda, Hong Yin, and Chihiro Sugimoto, “A Pilot Study on Developing Mucosal Vaccine against Alveolar Echinococcosis (AE) Using Recombinant Tetraspanin 3: Vaccine Efficacy and Immunology,” Plos Neglected Tropical Diseases, vol. 6, no. 3, 2012. View at PublisherView at Google Scholar
  • Justin Komguep Nono, Katrien Pletinckx, Manfred B. Lutz, and Klaus Brehm, “Excretory/Secretory-Products of Echinococcus multilocularis Larvae Induce A poptosis and Tolerogenic Properties in Dendritic Cells In Vitro,” Plos Neglected Tropical Diseases, vol. 6, no. 2, 2012. View at PublisherView at Google Scholar
  • P. D. Olson, M. Zarowiecki, F. Kiss, and K. Brehm, “Cestode genomics - progress and prospects for advancing basic and applied aspects of flatworm biology,” Parasite Immunology, vol. 34, no. 2-3, pp. 130–150, 2012. View at PublisherView at Google Scholar
  • Alain Beschin, Patrick De Baetselier, and Jo A Van Ginderachter, “Contribution of myeloid cell subsets to liver fibrosis in parasite infection,” The Journal of Pathology, vol. 229, no. 2, pp. 186–197, 2012. View at PublisherView at Google Scholar
  • YuRong Yang, Magda K. Ellis, and Donald P. McManus, “Immunogenetics of human echinococcosis,” Trends in Parasitology, vol. 28, no. 10, pp. 447–454, 2012. View at PublisherView at Google Scholar
  • Thomas F. E. Barth, Petra Kern, Hanns M. Seitz, Peter Möller, Robert L. Rausch, Peter Kern, Peter Deplazes, Tobias S. Herrmann, Dennis Tappe, Lorenz Stark, Beate Grüner, Klaus Buttenschoen, Andreas Hillenbrand, Markus Juchems, and Doris Henne-Bruns, “Sensitive and Specific Immunohistochemical Diagnosis of Human Alveolar Echinococcosis with the Monoclonal Antibody Em2G11,” PLoS Neglected Tropical Diseases, vol. 6, no. 10, 2012. View at PublisherView at Google Scholar
  • Chuanshan Zhang, Junhua Wang, Guodong Lu, Jing Li, Xiaomei Lu, Georges Mantion, Dominique A. Vuitton, Hao Wen, and Renyong Lin, “Hepatocyte Proliferation/Growth Arrest Balance in the Liver of Mice during E-multilocularis Infection: A Coordinated 3-Stage Course,” Plos One, vol. 7, no. 1, pp. 436–452, 2012. View at PublisherView at Google Scholar
  • Tatiana Basika, Natalia MuÑOz, Cecilia Casaravilla, Florencia IrigoÍN, Carlos BatthyÁNy, Mariana Bonilla, Gustavo Salinas, JosÉ Pedro Pacheco, Johaness Roth, Rosario DurÁN, and Alvaro DÍAz, “Phagocyte-specific S100 proteins in the local response to the Echinococcus granulosus larva,” Parasitology, vol. 139, no. 02, pp. 271–283, 2012. View at PublisherView at Google Scholar
  • Wenbao Zhang, Hao Wen, Jun Li, Renyong Lin, and Donald P. McManus, “Immunology and Immunodiagnosis of Cystic Echinococcosis: An Update,” Clinical and Developmental Immunology, vol. 2012, pp. 1–10, 2012. View at PublisherView at Google Scholar
  • Annalisa Agnone, Alessandra Torina, Gesualdo Vesco, Sara Villari, Fabrizio Vitale, Santo Caracappa, Marco Pio La Manna, Francesco Dieli, and Guido Sireci, “Antigen-Specific T Cells and Cytokines Detection as Useful Tool for Understanding Immunity against Zoonotic Infections,” Clinical and Developmental Immunology, vol. 2012, pp. 1–8, 2012. View at PublisherView at Google Scholar
  • Yadong Zheng, “Strategies of Echinococcus species responses to immune attacks: Implications for therapeutic tool development,” International Immunopharmacology, 2013. View at PublisherView at Google Scholar
  • Kerstin Wahlers, Colin N. Menezes, Thomas Romig, Peter Kern, and Martin P. Grobusch, “Cystic Echinococcosis in South Africa: The worst yet to come?,” Acta Tropica, 2013. View at PublisherView at Google Scholar
  • A. Chauchet, C. Richou, D. A. Vuitton, J. Knapp, L. Milton, and S. Bresson-Hadni, “Alveolar echinococcosis: Epidemiology, survey and management,” Journal des Anti-Infectieux, vol. 15, no. 4, pp. 204–214, 2013. View at PublisherView at Google Scholar
  • Nannan Pang, Fengbo Zhang, Xiumin Ma, Yuejie Zhu, Hui Zhao, Yan Xin, Song Wang, Zhaolun Chen, Hao Wen, and Jianbing Ding, “TGF-β/Smad signaling pathway regulates Th17/Treg balance during Echinococcus multilocularis infection,” International Immunopharmacology, 2014. View at PublisherView at Google Scholar
  • Sarah Hemer, Christian Konrad, Markus Spiliotis, Uriel Koziol, Dominik Schaack, Sabine Foerster, Verena Gelmedin, Britta Stadelmann, Thomas Dandekar, and Andrew Hemphill, “Host insulin stimulates Echinococcus multilocularis insulin signalling path ways and larval development,” Bmc Biology, vol. 12, 2014. View at PublisherView at Google Scholar
  • Nannan Pang, Fengbo Zhang, Xiumin Ma, Zhaoxia Zhang, Hui Zhao, Yan Xin, Song Wang, Yuejie Zhu, Hao Wen, and Jianbing Ding, “Th9/IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus,” Mediators of Inflammation, vol. 2014, pp. 1–11, 2014. View at PublisherView at Google Scholar