Hypomethylation of IL10 and IL13 Promoters in CD4⁺ T Cells of Patients with Systemic Lupus Erythematosus

Figure 2

IL10 and IL13 mRNA expression in CD4⁺ T cells from SLE patients (𝑛=15) and healthy controls (𝑛=15) and the relationship between expression and disease activity. (a) and (b) IL10 and IL13 mRNA levels in CD4⁺ T cells were measured by quantitative real-time PCR and normalized to 𝛽-actin (SLE versus healthy control, 𝑃=.007 and 𝑃=.006, respectively). (c) In SLE patients, IL10 mRNA expression correlated (𝑟=0.746) with SLEDAI score (𝑃=.001). (d) IL13 mRNA expression also correlated with disease activity (𝑟=0.628, 𝑃=.012).

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