Review Article

Interferon Alpha in Systemic Lupus Erythematosus

Figure 2

Multiple genes involved in interferon production and regulation are associated with risk for lupus. Shown are components of the signal transduction pathway from TLR stimulation by nucleic acids to IFN production. Genes that have been associated with risk for lupus are marked (*). IFN: interferon, IRAK: interleukin-1 receptor-associated kinase, IRF: interferon regulatory factor, MyD88: myeloid differentiation primary response gene 88, OPN: osteopontin, pDC: plasmacytoid dendritic cell, TLR: toll-like receptor, TNFAIP3: tumor necrosis factor alpha induced protein 3, TNIP1: TNFAIP3 interacting protein 1, and TRAF6: tumor necrosis factor receptor-associated factor 6.
948364.fig.002