Quantitative Proteomics Analysis of Maternal Plasma in Down Syndrome Pregnancies Using Isobaric Tagging Reagent (iTRAQ)

Table 2

List of the protein identified as up-regulated from the iTRAQ experiment, indicating is the biological process and molecular function of these proteins. (P value. 001).

No.	Acc. number	% Cov	Protein name	Biological processes	Molecular functions
1	P20742	31.5	Pregnancy zone protein	Ligand-mediated signaling	Other cytokine
2	P04003	30	C4b-binding protein alpha chain	Complement-mediated immunity	Complement component
3	P01842	68.6	Ig lambda chain C regions	Immunity	Immunoglobulin
4	P01233	26.1	Choriogonadotropin subunit beta	mRNA transcription	Other signaling molecule
5	P43251	14.1	Biotinidase	Vitamin metabolism	Other hydrolase
6	P01834	84	Ig kappa chain C region	Immunity	Immunoglobulin
7	P01859	42	Ig gamma-2 chain C region	Immunity	Immunoglobulin
8	P01215	6	Glycoprotein hormones alpha chain	Protein targeting and localization	SNARE protein
9	P80108	16.5	Phosphatidylinositol-glycan	Intracellular signaling cascade	Lipase
10	P01860	53.8	Ig gamma-3 chain C region	B-cell- and antibody-mediated immunity	Immunoglobulin
11	Q9UGM5	27.5	Fetuin-B	Intracellular signaling cascade	Lipase
12	P35858	26	Insulin-like growth factor	Cell adhesion	Receptor
13	P26927	22.9	Hepatocyte growth factor-like protein	Ligand-mediated signaling	Growth factor
14	P02751	49.4	Fibronectin	Extracellular matrix protein	Cell adhesion molecule
15	P02743	54.3	Serum amyloid P-component	Amino acid biosynthesis	Synthase
16	P00751	37.7	Complement factor B	Proteolysis	Serine protease
17	P01031	42.6	Complement C5	Complement-mediated immunity	Complement component
18	P07358	36.5	Complement component C8 beta chain	Complement-mediated immunity	Complement component
19	P02790	67.3	Hemopexin	Vitamin/cofactor transport	Carrier protein
20	P00734	61.3	Prothrombin	Blood clotting	Serine protease
21	Q14624	54.8	Inter-alpha-trypsin inhibitor heavy chain H4	Proteolysis	Serine protease inhibitor
22	O00213	10.8	Amyloid beta A4	Other neuronal activity	Other signaling molecule
23	P08603	61.7	Complement factor H	Complement-mediated immunity	Complement component
24	P00738	53	Haptoglobin	Neurotransmitter release	Vesicle coat protein
25	P22891	10.3	Vitamin K-dependent protein Z	Proteolysis	Serine protease
26	P22792	14.1	Carboxypeptidase N subunit 2	Cell surface receptor	Receptor
27	P07357	27.9	Complement component C8	Complement-mediated immunity	Complement component
28	P02741	8.9	C-reactive protein	Stress response	Defense and immunity