BioMed Research International / 2010 / Article / Tab 3 / Research Article
Quantitative Proteomics Analysis of Maternal Plasma in Down Syndrome Pregnancies Using Isobaric Tagging Reagent (iTRAQ) Table 3 List of the protein identified as down regulated from the iTRAQ experiment, indicating is the biological process and molecular function of these proteins. (P value .001).
No. Acc. number %Cov Protein name Biological processes Molecular functions 1 P01009 32.8 Alpha-1-antitrypsin Nerve-nerve synaptic transmission Glutamate receptor 2 P02768 67 Serum albumin Amino acid biosynthesis Reductase 3 P63261 49.1 Actin, cytoplasmic 2 (Gamma-actin) Cell structure Actin and actin related protein 4 O95445 32.4 Apolipoprotein M (Apo-M) Lipid transport Plasma protein 5 P06727 67.7 Apolipoprotein A-IV Lipid and fatty acid transport Transporter 6 P02775 41.4 Platelet basic protein Pyrimidine metabolism Phosphorylase 7 P02647 85.8 Apolipoprotein A-I Lipid and fatty acid transport Transporter 8 P01023 39.8 Alpha-2-macroglobulin Developmental processes Serine/threonine kinase 9 P02787 58.9 Serotransferrin Amino acid biosynthesis Synthase 10 P04275 11.3 von Willebrand factor Cell adhesion Extracellular matrix glycoprotein 11 P02671 35.2 Fibrinogen alpha chain Cell proliferation and differentiation Extracellular matrix glycoprotein 12 P01024 29.6 Complement C3 Nerve-nerve synaptic transmission Glutamate receptor 13 P98160 5.1 Heparan sulfate proteoglycan Extracellular matrix Cell adhesion mediated signal 14 P51884 33.4 Lumican Receptor Cell adhesion-mediated signaling 15 P04114 41.5 Apolipoprotein B-100 Lipid and fatty acid transport Component of serum lipoproteins 16 Q8WZ42 9.5 Titin (EC 2.7.11.1) (Connectin) Muscle contraction Actin binding cytoskeletal protein 17 P08519 11 Apolipoprotein(a) Cell proliferation and differentiation Peptide hormone 18 P43652 47.7 Afamin Transport Other transfer/carrier protein 19 P06396 54.9 Gelsolin Cell structure Nonmotor actin binding protein 20 P02749 54.2 Beta-2-glycoprotein 1 Amino acid metabolism Transaminase 21 Q9NYC9 4.8 Dynein heavy chain 9 Force generating protein ATPase activity 22 P32119 4 Peroxiredoxin-2 Redox regulation Eliminating peroxides