Claudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers

<table>A hypothetical model of claudin 1 expression in different breast cancer subtypes.  This model proposes that claudin 1 is a tumor suppressor in the ER<svg height="9.3125" id="M29" style="vertical-align:-0.51414pt" version="1.1" viewbox="0 0 10.825 9.3125" width="10.825" xmlns="http://www.w3.org/2000/svg">
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</svg>ve subtypes of breast cancer (luminal A and B) and a tumor enhancer/facilitator in the ER<svg height="4.5999999" id="M30" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.825 4.5999999" width="10.825" xmlns="http://www.w3.org/2000/svg">
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</svg>ve subtypes (basal-like, Her2 over expressing, normal-like). Whereas a significant association between claudin 1 and the basal-like subtype has been demonstrated, this is yet to be determined for the Her2 over expressing and the normal-like subtypes.</table>

BioMed Research International

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Figure 3: Claudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers 