Claudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers

Table 1

The five distinct subtypes of breast cancer and their corresponding phenotypes.

Subtypes	Phenotype	BC Cell Lines	References
Luminal A	ER+ve and/or PR+ve, Her2−ve	MCF7, T47D, ZR75-1	[3, 6, 9, 16]
Luminal B	ER+ve and/or PR+ve, Her2+ve	MDA361, BT474, ZR75-30	[3, 6, 9, 16]
Her2 overexpressing	ER−ve, PR−ve, Her2+ve	HCC202, HCC1419, HCC1569, HCC1954	[3, 6, 16]
Basal-like	ER−ve, PR−ve, Her2−ve, CK5,6+ve and/or EGFR+ve		BT20, MDA231, MDA468	[3, 6–8, 16, 17]
Normal-like		not clearly defined, similar to normal epithelia, displays putative-initiating stem cell phenotype	N/A	[3, 6, 10]

BC: breast cancer; ER: estrogen receptor; PR: progesterone receptor; Her2: human epidermal growth factor receptor 2; CK5,6: cytokeratin 5, 6; EGFR: epidermal growth factor receptor; +ve: positive; −ve: negative; N/A: not available.