Claudin 1 in Breast Tumorigenesis: Revelation of a Possible Novel “Claudin High” Subset of Breast Cancers
Table 2
Chromosomal locations of the 24 members of the claudin gene family and examples of their tissue-specific gene expression in normal and neoplastic tissues. Homologues for all members of this family (except CLDN21) are also found in chimpanzee, mouse, dog, rat, chicken, and fish.
Gene
Human Chromosomal Location
Tissue Expression1
Breast
Prostate
Lung
Liver
Normal
Cancer
Normal
Cancer
Normal
Cancer
Normal
Cancer
CLDN1
3q28-q29
8.7
2.4
1.5
0.8
5.0
10.1
21.1
14.9
CLDN2
Xq22.3-q23
0.5
1.1
0.7
1.2
1.3
2.5
0.0
0.0
CLDN3
7q11.23
29.2
85.1
7.5
37.8
1.3
47.8
6.0
7.4
CLDN4
7q11.23
134.5
192.8
6.0
27.2
10.0
70.4
0.0
14.9
CLDN5
22q11.21
8.7
3.2
0.7
0.4
7.5
2.5
0.0
0.0
CLDN6
16p13.3
0.3
0.5
0.0
0.0
0.0
0.0
0.0
0.0
CLDN7
17p13
20.4
13.4
24.0
9.8
7.5
25.1
0.0
37.2
CLDN8
21q22.11
0.9
0.4
0.7
0.4
0.0
0.0
0.0
0.0
CLDN9
16p13.3
0.3
1.7
0.0
0.0
0.0
0.0
0.0
0.0
CLDN10
13q31-q34
0.3
0.1
0.7
0.4
0.0
1.3
0.0
0.9
CLDN11
3q26.2-q26.3
1.7
1.0
1.5
0.8
0.0
0.0
0.0
2.8
CLDN12
7q21
12.4
9.3
3.7
4.5
15.0
1.3
15.1
6.5
CLDN13*
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
CLDN14
21q22.3
0.0
0.6
0.0
0.0
0.0
0.0
0.0
0.0
CLDN15
7q11.22
1.9
2.5
0.7
2.8
0.0
7.5
0.0
1.9
CLDN16
3q28
0.0
0.1
0.0
0.0
0.0
0.0
0.0
0.0
CLDN17
21q22.11
0.2
0.1
0.0
0.0
0.0
0.0
0.0
0.0
CLDN18
3q22.3
0.0
0.0
0.0
0.0
2.5
1.3
0.0
0.0
CLDN19
1p34.2
0.0
0.1
0.0
0.0
0.0
0.0
0.0
0.0
CLDN20
6q25
0.2
0.7
0.0
3.3
0.0
1.3
0.0
1.9
CLDN21
4q35.1
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
CLDN22
4q35.1
2.6
5.5
7.5
6.5
3.8
5.0
9.0
6.5
CLDN23
8p23.1
2.1
5.7
14.2
23.2
11.3
8.8
3.0
11.2
CLDN24
4q35.1
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
1Relative gene expression (SAGE data) derived from the Cancer Genome Anatomy Project (CGAP [50]).
*Mouse only; N/A: not available; 0.0: not detected Numbers in columns indicate the number of tags/200,000 for each tissue/histology.
