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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 101497, 8 pages
http://dx.doi.org/10.1155/2011/101497
Research Article

Molecular Imaging, Pharmacokinetics, and Dosimetry of 111In-AMBA in Human Prostate Tumor-Bearing Mice

1Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan
2Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 11221, Taiwan

Received 7 December 2010; Accepted 7 March 2011

Academic Editor: Hong Zhang

Copyright © 2011 Chung-Li Ho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer Journal for Clinicians, vol. 59, no. 4, pp. 225–249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. V. Erspamer, G. F. Erpamer, and M. Inselvini, “Some pharmacological actions of alytesin and bombesin,” Journal of Pharmacy and Pharmacology, vol. 22, no. 11, pp. 875–876, 1970. View at Scopus
  3. G. S. Kroog, R. T. Jensen, and J. F. Battey, “Mammalian bombesin receptors,” Medicinal Research Reviews, vol. 15, no. 5, pp. 389–417, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Ohki-Hamazaki, M. Iwabuchi, and F. Maekawa, “Development and function of bombesin-like peptides and their receptors,” International Journal of Developmental Biology, vol. 49, no. 2-3, pp. 293–300, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. R. T. Jensen, J. F. Battey, E. R. Spindel, and R. V. Benya, “International union of pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states,” Pharmacological Reviews, vol. 60, no. 1, pp. 1–42, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. E. Maddalena, J. Fox, J. Chen et al., “Lu-AMBA biodistribution, radiotherapeutic efficacy, imaging, and autoradiography in prostate cancer models with low GRP-R expression,” Journal of Nuclear Medicine, vol. 50, no. 12, pp. 2017–2024, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Nagy and A. V. Schally, “Targeting cytotoxic conjugates of somatostatin, luteinizing hormone-releasing hormone and bombesin to cancers expressing their receptors: a “smarter” chemotherapy,” Current Pharmaceutical Design, vol. 11, no. 9, pp. 1167–1180, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. J. K. Willmann, N. van Bruggen, L. M. Dinkelborg, and S. S. Gambhir, “Molecular imaging in drug development,” Nature Reviews Drug Discovery, vol. 7, no. 7, pp. 591–607, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Lammers, F. Kiessling, W. E. Hennink, and G. Storm, “Nanotheranostics and image-guided drug delivery: current concepts and future directions,” Molecular Pharmaceutics, vol. 7, no. 6, pp. 1899–1912, 2010. View at Publisher · View at Google Scholar
  10. R. Markwalder and J. C. Reubi, “Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation,” Cancer Research, vol. 59, no. 5, pp. 1152–1159, 1999. View at Scopus
  11. C.-L. Ho, L.-C. Chen, W.-C. Lee et al., “Receptor-binding, biodistribution, dosimetry, and micro-SPECT/CT imaging of 111In-[DTPA1, Lys3, Tyr4]-bombesin analog in human prostate tumor-bearing mice,” Cancer Biotherapy and Radiopharmaceuticals, vol. 24, no. 4, pp. 435–443, 2009. View at Publisher · View at Google Scholar
  12. W. A. P. Breeman, M. De Jong, B. F. Bernard et al., “Pre-clinical evaluation of [111In-DTPA-Pro1, Tyr4]bombesin, a new radioligand for bombesin-receptor scintigraphy,” International Journal of Cancer, vol. 83, no. 5, pp. 657–663, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. W. A. P. Breeman, M. De Jong, J. L. Erion et al., “Preclinical comparison of In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy,” Journal of Nuclear Medicine, vol. 43, no. 12, pp. 1650–1656, 2002. View at Scopus
  14. M. De Visser, H. F. Bernard, J. L. Erion et al., “Novel 111In-labelled bombesin analogues for molecular imaging of prostate tumours,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, no. 8, pp. 1228–1238, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. M. F. Tweedle, “Peptide-targeted diagnostics and radiotherapeutics,” Accounts of Chemical Research, vol. 42, no. 7, pp. 958–968, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. J. G. Kereiakes and D. V. Rao, “Auger electron dosimetry: report of AAPM Nuclear Medicine Committee Task Group No. 6,” Medical Physics, vol. 19, no. 6, pp. 1359–1360, 1992. View at Publisher · View at Google Scholar · View at Scopus
  17. I.-H. Liu, C.-H. Chang, C.-L. Ho et al., “Multimodality imaging and preclinical evaluation of 177Lu-AMBA for human prostate tumours in a murine model,” Anticancer Research, vol. 30, no. 10, pp. 4039–4048, 2010.
  18. J. C. Garrison, T. L. Rold, G. L. Sieckman et al., “Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7-14)NH structural paradigm in a prostate cancer model,” Bioconjugate Chemistry, vol. 19, no. 9, pp. 1803–1812, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. R. P. J. Schroeder, C. Müller, S. Reneman et al., “A standardised study to compare prostate cancer targeting efficacy of five radiolabelled bombesin analogues,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 37, no. 7, pp. 1386–1396, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Mansi, X. Wang, F. Forrer et al., “Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides,” Clinical Cancer Research, vol. 15, no. 16, pp. 5240–5249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Zhang, J. Chen, C. Waldherr et al., “Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with Indium-111, Lutetium-177, and Yttrium-90 for targeting bombesin receptor-expressing tumors,” Cancer Research, vol. 64, no. 18, pp. 6707–6715, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. W. H. Bakker, R. Albert, C. Bruns et al., “[111In-DTPA-D-Phe1]-octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: synthesis, radiolabeling and in vitro validation,” Life Sciences, vol. 49, no. 22, pp. 1583–1591, 1991. View at Publisher · View at Google Scholar · View at Scopus
  23. C. J. Smith, H. Gali, G. L. Sieckman et al., “Radiochemical investigations of 177Lu-DOTA-8-Aoc-BBN[7-14]NH: an in vitro/in vivo assessment of the targeting ability of this new radiopharmaceutical for PC-3 human prostate cancer cells,” Nuclear Medicine and Biology, vol. 30, no. 2, pp. 101–109, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. M. G. Stabin and J. A. Siegel, “Physical models and dose factors for use in internal dose assessment,” Health Physics, vol. 85, no. 3, pp. 294–310, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. E. M. Molina-Trinidad, C. A. D. Murphy, G. Ferro-Flores, E. Murphy-Stack, and H. Jung-Cook, “Radiopharmacokinetic and dosimetric parameters of 188Re-lanreotide in athymic mice with induced human cancer tumors,” International Journal of Pharmaceutics, vol. 310, no. 1-2, pp. 125–130, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. International Commission on Radiological Units and Measurements, “Absorbed-Dose Specification in Nuclear Medicine, ICRU Report 67,” Journal of the ICRU, vol. 2, no. 1, 2002.
  27. C. H. Chang, TA. K. Chou, C. Y. Yang, T. J. Chang, YU. H. Wu, and TE. W. Lee, “Biodistribution and pharmacokinetics of transgenic pig-produced recombinant human factor IX (rhFIX) in rats,” In Vivo, vol. 22, no. 6, pp. 693–698, 2008. View at Scopus
  28. S. Sotomayor, L. Muñoz-Moreno, M. J. Carmena et al., “Regulation of HER expression and transactivation in human prostate cancer cells by a targeted cytotoxic bombesin analog (AN-215) and a bombesin antagonist (RC-3095),” International Journal of Cancer, vol. 127, no. 8, pp. 1813–1822, 2010. View at Publisher · View at Google Scholar
  29. D. B. Cornelio, R. Roesler, and G. Schwartsmann, “Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy,” Annals of Oncology, vol. 18, no. 9, pp. 1457–1466, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Maina, B. A. Nock, H. Zhang et al., “Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs,” Journal of Nuclear Medicine, vol. 46, no. 5, pp. 823–830, 2005. View at Scopus
  31. J. L. Scemama, A. Zahidi, and D. Fourmy, “Interaction of [125I]-Tyr-bombesin with specific receptors on normal human pancreatic membranes,” Regulatory Peptides, vol. 13, no. 2, pp. 125–132, 1986. View at Scopus
  32. B. Waser, V. Eltschinger, K. Linder, A. Nunn, and J. C. Reubi, “Selective in vitro targeting of GRP and NMB receptors in human tumours with the new bombesin tracer Lu-AMBA,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, no. 1, pp. 95–100, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. C. J. Smith, W. A. Volkert, and T. J. Hoffman, “Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes,” Nuclear Medicine and Biology, vol. 32, no. 7, pp. 733–740, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Louis, “Octreoscan kit for the preparation of indium-111 pentetreotide [product monograph],” 1995.
  35. M. Ferrari, M. Cremonesi, M. Bartolomei et al., “Dosimetric model for locoregional treatments of brain tumors with Y-conjugates: clinical application with Y-DOTATOC,” Journal of Nuclear Medicine, vol. 47, no. 1, pp. 105–112, 2006. View at Scopus
  36. E. P. Krenning, P. P. M. Koolj, W. H. Bakker et al., “Radiotherapy with a radiolabeled somatostatin analogue, [111In-DTPA-D-Phe1]-Octreotide. A case history,” Annals of the New York Academy of Sciences, vol. 733, pp. 496–506, 1994. View at Publisher · View at Google Scholar · View at Scopus
  37. L. E. Lantry, E. Cappelletti, M. E. Maddalena et al., “177Lu-AMBA: synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer,” Journal of Nuclear Medicine, vol. 47, no. 7, pp. 1144–1152, 2006. View at Scopus