Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications

Table 1

Genetic abnormalities commonly detected in combination with t(8;21).

Abnormality	Frequency in t(8;21) AML	Documented prognostic impact	Reference
Chromosomal abnormalities
-X in female patients	30%–40%	None	[7, 24, 25]
-Y in male patients	50%–60%	Possible improved	[7, 24, 25]
Del(9q)	15%–35%; most studies state 15%–20%	None	[7, 24–26]
Trisomy 8	8%		[27]
Complex abnormalities	9%–23%	Adverse prognosis	[27–29]
Molecular abnormalities
KIT mutations	25%–50%	Possible adverse prognosis	[30–41]
JAK2V617F	6%–8%		[36, 42]
Flt3 -ITD	5%	Adverse prognosis	[24, 33, 43]
Flt3 D853	3%–7%		[24, 43]