Review Article

Herpesvirus BACs: Past, Present, and Future

Table 1

BAC-based human herpesvirus studies.

VirusGlobal deletion?Representative studies

Herpes Simplex Virus-1 (HSV-1)NoHorsburgh et al. 1999 [17]
Saeki et al. 1998 [18]
Stavropoulos and Strathdee 1998 [19]

Herpes Simplex Virus-2 (HSV-2)NoMeseda et al. 2004 [20]

Varicella Zoster Virus (VZV)YesNagaike et al. 2004 [21]
Zhang et al. 2007 [22]
Wussow et al. 2009 [23]

Epstein-Barr Virus (EBV)NoDelecluse et al. 1998 [24]

Cytomegalovirus (CMV)YesBorst et al. 1999 [25]
Marchini et al. 2001 [26]
Hahn et al. 2002 [27]
Murphy et al. 2003 [28]
Sinzger et al., 2008 [29]
Dulal et al. 2009 [30]

Human Herpesvirus 6 (HHV-6)NoBorenstein and Frenkel 2009 [31]

Human Herpesvirus 7 (HHV-7)No BACNA

Kaposi’s Sarcoma-Associated Herpesvirus (KSHV)NoDelecluse et al. 2001 [32]
Zhou et al. 2002 [33]

In most cases, “representative studies” represent the first BAC produced for each human herpesvirus. Hahn et al. 2002, Marchini et al. 2001, and Murphy et al. 2002 correspond to creation of BACs for other alternative strains of HCMV. Zhang et al. 2007 and Dulal et al. 2009 refer to the first BACs with a luciferase reporter genes.