Herpesvirus BACs: Past, Present, and Future

Table 2

Selected BAC-based animal herpesvirus studies.

Virus	Global deletion?	Representative studies
Bovine Herpesvirus Type 1 (BHV-1)	Yes	Mahony et al. 2002 [34]
		Robinson et al. 2008 [35]
Equine Herpesvirus Type 1 (EHV-1)	No	Rudolph et al. 2002 [36]
Feline Herpesvirus Type 1 (FHV-1)	No	Costes et al. 2006 [37]
Guinea Pig Cytomegalovirus (GPCMV)	No	McGregor and Schleiss 2001 [38]
Herpesvirus Saimiri (HVS)	No	White et al. 2003 [39]
Koi Herpesvirus (KHV)	No	Costes et al. 2008 [40]
Marek's Disease Virus (MDV)	No	Schumacher et al. 2000 [41]
Murine Cytomegalovirus (mCMV)	Yes	Messerle et al. 1997 [12]
		Brune et al. 1999 [42]
		Bubeck et al. 2004 [43]
Murine Gammaherpesvirus 68 (MHV-68)	Yes	Adler et al. 2000 [44]
		Song et al. 2005 [45]
Pseudorabies Virus (PrV)	No	Smith and Enquist 1999 [46]
Rhesus Cytomegalovirus (rhCMV)	No	Chang and Barry 2003 [47]
Rhesus Rhadinovirus (RRV)	No	Estep et al. 2007 [48]
Turkey Herpesvirus (HVT)	No	Baigent et al. 2006 [49]

In most cases, important BACs represent the first BAC produced for a given virus. The work of Brune et al. (1999), Bubeck et al. (2004), Robinson et al. (2008), and Song et al. (2005) are global mutagenesis studies.