Table 1: Subcellular localization and functions of nonhistone substrates of HDAC3.

Substrates Localization of substrates Functions Comments MEF2 Nucleus Repression of MyoD promoter HDAC3 is the only Class I HDAC that regulates MEF2 activity SRY Nucleus Nuclear export Deacetylation leads to cytoplasmic delocalization Cytoplasmic translocation promotes apoptosis PCAF Nucleus Cytoplasmic retention Functional interplay between PCAF and HDAC3 STAT1 Cytoplasm Prevention of STAT1 phosphorylation STAT3 Cytoplasm Prevention of dimerization NF-B Cytoplasm or nucleus Cytoplasmic retention or activation of p65 in the nucleus Functions are dependent on the acetylation lysines