Table 3: Proteins interacting with and inhibiting the deacetylase activity of HDAC6.

Interacting proteinsSubstrates affectedFunctions involvedReferences

TPPP/p25TubulinDecrease cell mobility[59]
CYLDTubulinCell proliferation[60]
IIp45Tubulin (decreases stability of HDAC6)Cell migration[61]
TauTubulinPrevent autophagy[62]
EGFRTubulin (decreases deacetylase activity of HDAC6 by phosphorylation)Decrease endocytosis and degradation[63]