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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 159834, 5 pages
http://dx.doi.org/10.1155/2011/159834
Research Article

Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection: A Preliminary Study with MicroPET

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

Received 30 December 2010; Accepted 16 February 2011

Academic Editor: Mei Tian

Copyright © 2011 Chenxi Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Brown adipose tissue (BAT) is emerging as a potential target for treating human obesity. It has been indicated that BAT is rich in innervations of sympathetic nerve control. Using 18F-FDG microPET imaging, this study aims at evaluating how factors related to sympathetic activation/inhibition changed BAT metabolism of mice. BAT 18F-FDG uptake were semiquantitatively evaluated in different groups of mice under temperature (cold or warm stimulus) or pharmacological interventions (norepinephrine, epinephrine, isoprenaline, or propranolol) and were compared with the corresponding controls. It was found that BAT activation can be stimulated by cold exposure ( 𝑃 = 1 . 9 6 Γ— 1 0 βˆ’ 4 ), norepinephrine ( 𝑃 = . 0 0 2 ), or both ( 𝑃 = 2 . 1 9 Γ— 1 0 βˆ’ 6 ) within an hour before 18F-FDG injection and can also be alleviated by warming up ( 𝑃 = . 0 0 1 ) or propranolol lavage ( 𝑃 = . 0 2 7 ). This preliminary study indicated that BAT function could be evaluated by 18F-FDG PET imaging through short-term interventions, which paved the way for further investigation of the relationship between human obesity and BAT dysfunction.