About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 159834, 5 pages
http://dx.doi.org/10.1155/2011/159834
Research Article

Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection: A Preliminary Study with MicroPET

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

Received 30 December 2010; Accepted 16 February 2011

Academic Editor: Mei Tian

Copyright © 2011 Chenxi Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Ghorbani, T. H. Claus, and J. Himms-Hagen, “Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β-adrenoceptor agonist,” Biochemical Pharmacology, vol. 54, no. 1, pp. 121–131, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Frühbeck, S. Becerril, N. Sáinz, P. Garrastachu, and M. J. García-Velloso, “BAT: a new target for human obesity?” Trends in Pharmacological Sciences, vol. 30, no. 8, pp. 387–396, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Hull, “The structure and function of brown adipose tissue,” British Medical Bulletin, vol. 22, no. 1, pp. 92–96, 1966. View at Scopus
  4. J. Nedergaard, T. Bengtsson, and B. Cannon, “Unexpected evidence for active brown adipose tissue in adult humans,” American Journal of Physiology, vol. 293, no. 2, pp. E444–E452, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. M. Cypess and C. R. Kahn, “Brown fat as a therapy for obesity and diabetes,” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 17, no. 2, pp. 143–149, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. B. Hansen and K. Kristiansen, “Regulatory circuits controlling white versus brown adipocyte differentiation,” Biochemical Journal, vol. 398, no. 2, pp. 153–168, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. P. G. Shekelle, M. L. Hardy, S. C. Morton et al., “Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis,” Journal of the American Medical Association, vol. 289, no. 12, pp. 1537–1545, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. A. Van Baak, G. B. J. Hul, S. Toubro et al., “Acute effect of L-796568, a novel β-adrenergic receptor agonist, on energy expenditure in obese men,” Clinical Pharmacology and Therapeutics, vol. 71, no. 4, pp. 272–279, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. W. D. Van Marken Lichtenbelt, J. W. Vanhommerig, N. M. Smulders et al., “Cold-activated brown adipose tissue in healthy men,” New England Journal of Medicine, vol. 360, no. 15, pp. 1500–1508, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. B. J. Fueger, J. Czernin, I. Hildebrandt et al., “Impact of animal handling on the results of F18-FDG PET studies in mice,” Journal of Nuclear Medicine, vol. 47, no. 6, pp. 999–1006, 2006. View at Scopus
  11. J. Himms-Hagen, “Role of thermogenesis in the regulation of energy balance in relation to obesity,” Canadian Journal of Physiology and Pharmacology, vol. 67, no. 4, pp. 394–401, 1989.
  12. M. Watanabe, T. Yamamoto, C. Mori et al., “Cold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis,” Biological and Pharmaceutical Bulletin, vol. 31, no. 5, pp. 775–784, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Atgié, F. D'Allaire, and L. J. Bukowiecki, “Role of β- and β-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes,” American Journal of Physiology, vol. 273, no. 4, pp. C1136–C1142, 1997. View at Scopus
  14. T. F. Hany, E. Gharehpapagh, E. M. Kamel, A. Buck, J. Himms-Hagen, and G. K. Von Schulthess, “Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region,” European Journal of Nuclear Medicine, vol. 29, no. 10, pp. 1393–1398, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Cohade, M. Osman, H. K. Pannu, and R. L. Wahl, “Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT,” Journal of Nuclear Medicine, vol. 44, no. 2, pp. 170–176, 2003. View at Scopus
  16. S. Basu and A. Alavi, “Optimizing interventions for preventing uptake in the brown adipose tissue in FDG-PET,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 35, no. 8, pp. 1421–1423, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Williams and G. M. Kolodny, “Method for decreasing uptake of F18-FDG by hypermetabolic brown adipose tissue on PET,” American Journal of Roentgenology, vol. 190, no. 5, pp. 1406–1409, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. K. A. Zukotynski, F. H. Fahey, S. Laffin et al., “Constant ambient temperature of 24°C significantly reduces FDG uptake by brown adipose tissue in children scanned during the winter,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 36, no. 4, pp. 602–606, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Xu, R. Bian, and X. Chen, Methodology of Pharmacology Experiment (Chinese), People’s Health Press, Beijing, China, 3rd edition, 2001.
  20. S. Baba, M. Tatsumi, T. Ishimori, D. L. Liliein, J. M. Engles, and R. L. Wahl, “Effect of nicotine and ephedrine on the accumulation of F18-FDG in brown adipose tissue,” Journal of Nuclear Medicine, vol. 48, no. 6, pp. 981–986, 2007. View at Publisher · View at Google Scholar · View at Scopus