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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 165214, 7 pages
Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer
Department of General Surgical Science, Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
Received 19 January 2011; Accepted 11 April 2011
Academic Editor: Dominic Fan
Copyright © 2011 Takayuki Kosaka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [59 citations]
The following is the list of published articles that have cited the current article.
- Yi-fan Chen, and Li-wu Fu, “Mechanisms of acquired resistance to tyrosine kinase inhibitors,” Acta Pharmaceutica Sinica B, vol. 1, no. 4, pp. 197–207, 2011.
- F. Chen, R. Miyahara, T. Sato, M. Sonobe, H. Sakai, T. Bando, and H. Date, “Usefulness of endobronchial ultrasound in patients with previously treated thoracic malignancy,” Interactive CardioVascular and Thoracic Surgery, vol. 14, no. 1, pp. 34–37, 2011.
- Charles V. Rajadurai, Serhiy Havrylov, Kossay Zaoui, Richard Vaillancourt, Matthew Stuible, Monica Naujokas, Dongmei Zuo, Michel L. Tremblay, and Morag Park, “Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia,” Journal Of Cell Science, vol. 125, no. 12, pp. 2940–2953, 2012.
- P. Hofman, and M. Ilie, “Pitfalls in Lung Cancer Molecular Pathology: How to Limit them in Routine Practice?,” Current Medicinal Chemistry, vol. 19, no. 16, pp. 2638–2651, 2012.
- V. Hirsh, B. Melosky, G. Goss, D. Morris, and W. Morzycki, “A personalized approach to treatment: use of EGFR tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer in Canada,” Current Oncology, vol. 19, no. 2, pp. 78–90, 2012.
- Vera Hirsh, “Re. Karam I, Melosky B. Response to second-line erlotinib in an EGFR mutation-negative patient with non-small-cell lung cancer: make no assumptions. Curr Oncol 2012;19:42-6.,” Current Oncology, vol. 19, no. 1, pp. 21–22, 2012.
- Carolina H. Thomé, Alice Chin, Samir M. Hanash, Roberto P. Falcão, Eduardo M. Rego, Lewis J. Greene, Vitor M. Faça, Guilherme A. Dos Santos, Germano A. Ferreira, Priscila S. Scheucher, Clarice Izumi, Andreia M. Leopoldino, Ana Maria Simão, Pietro Ciancaglini, and Kleber T. De Oliveira, “Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity,” Molecular and Cellular Proteomics, vol. 11, no. 12, pp. 1898–1912, 2012.
- Linette Castillo-Pichardo, and Suranganie F. Dharmawardhane, “Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer,” Nutrition and Cancer, vol. 64, no. 7, pp. 1058–1069, 2012.
- Jasmine G. Lee, and Reen Wu, “Combination Erlotinib-Cisplatin and Atg3-Mediated Autophagy in Erlotinib Resistant Lung Cancer,” Plos One, vol. 7, no. 10, 2012.
- Sun Mi Kim, Byoung Chul Cho, Oh-Joon Kwon, Yun Kyoung Hong, Joo Hang Kim, Flavio Solca, Sang-Jun Ha, Ross A. Soo, James G. Christensen, and Ji Hyun Lee, “Activation of IL-6R/JAK1/STAT3 signaling induces De Novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation,” Molecular Cancer Therapeutics, vol. 11, no. 10, pp. 2254–2264, 2012.
- Xiaochun Wang, Philip J. Crowe, David Goldstein, and Jia-Lin Yang, “STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (Review),” International Journal of Oncology, vol. 41, no. 4, pp. 1181–1191, 2012.
- Pawel Krawczyk, Radoslaw Mlak, Tomasz Powrozek, Marcin Nicos, Dariusz M. Kowalski, Kamila Wojas-Krawczyk, and Janusz Milanowski, “Mechanisms of resistance to reversible inhibitors of EGFR tyrosine kinase in non-small cell lung cancer,” Wspolczesna Onkologia-Contemporary Oncology, vol. 16, no. 5, pp. 401–406, 2012.
- Xiao-Hui Zhou, Li-Na Tang, Lu Yue, Da-Liu Min, Yi Yang, Jian-An Huang, and Zan Shen, “HGFK1 is Associated with a Better Prognostis and Reverses Inhibition by Gefitinib in NSCLC Cases,” Asian Pacific Journal Of Cancer Prevention, vol. 13, no. 4, pp. 1457–1461, 2012.
- Ruili Han, Xiaoli Wang, Diansheng Zhong, Juan Zhao, Zhe Chen, Linlin Sun, Jing Wang, and Jinbang Zhang, “Molecular mechanism of erlotinib resistance in epidermal growth factor receptor mutant non-small cell lung cancer cell line H1650,” Chinese Journal of Lung Cancer, vol. 15, no. 12, pp. 689–693, 2012.
- Alicia D. Powers, Bi Liu, Andrew G. Lee, and Sean P. Palecek, “Macroporous hydrogel micropillars for quantifying Met kinase activity in cancer cell lysates,” The Analyst, vol. 137, no. 17, pp. 4052, 2012.
- Mian Xie, Chao-Sheng He, Shen-Hai Wei, and Li Zhang, “Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo,” European Journal of Cancer, 2013.
- Kuete, and Efferth, “Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol,” Pharmazie, vol. 68, no. 7, pp. 608–615, 2013.
- Robert Roskoski, “The preclinical profile of crizotinib for the treatment of non-small-cell lung cancer and other neoplastic disorders,” Expert Opinion on Drug Discovery, pp. 1–15, 2013.
- Helmut H. Popper, Ulrike Gruber-Moesenbacher, Leonhard Müllauer, Georg Hutarew, Michael Vesely, Robert Pirker, Wolfgang Hilbe, Ferdinand Ploner, Ulrike Setinek, Wolfgang Hulla, Hans Maier, William Sterlacci, Klaus Kirchbacher, Rainer Kolb, Maximilian Hochmair, Gerald Webersinke, Elvira Stacher, Patricia Grabher, and Tamara Hernler, “Recommendations of the Austrian Working Group on Lung Pathology and Oncology for predictive molecular and immunohistochemical testing in non-small cell lung cancer,” memo - Magazine of European Medical Oncology, 2013.
- Vladimira Koudelakova, Magdalena Kneblova, Radek Trojanec, Jiri Drabek, and Marian Hajduch, “Non-small cell lung cancer - genetic predictors,” Biomedical Papers, 2013.
- Marybeth Sechler, Amber D. Cizmic, Sreedevi Avasarala, Michelle Van Scoyk, Christine Brzezinski, Nicole Kelley, Rama Kamesh Bikkavilli, and Robert A. Winn, “Non-small-cell lung cancer: Molecular targeted therapy and personalized medicine - Drug resistance, mechanisms, and strategies,” Pharmacogenomics and Personalized Medicine, vol. 6, no. 1, pp. 25–36, 2013.
- S. Tjulandin, V. Moiseyenko, V. Semiglazov, G. Manikhas, M. Learoyd, A. Saunders, M. Stuart, and U. Keilholz, “Phase I, dose-finding study of AZD8931, an inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling, in patients with advanced solid tumors,” Investigational New Drugs, 2013.
- Howard A. Burris, “Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway,” Cancer Chemotherapy and Pharmacology, vol. 71, no. 4, pp. 829–842, 2013.
- Magali Humbert, Michaela Medová, Daniel M. Aebersold, Andree Blaukat, Friedhelm Bladt, Martin F. Fey, Yitzhak Zimmer, and Mario P. Tschan, “Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells,” Biochemical and Biophysical Research Communications, vol. 431, no. 2, pp. 264–269, 2013.
- S. Carrera, A. Buque, E. Azkona, U. Aresti, B. Calvo, A. Sancho, M. Arruti, M. Nuño, I. Rubio, A. R. Lobera, C. Lopez, and G. L. Vivanco, “Epidermal growth factor receptor tyrosine-kinase inhibitor treatment resistance in non-small cell lung cancer: biological basis and therapeutic strategies,” Clinical and Translational Oncology, 2013.
- Minghui Zhang, Xiaosan Zhang, Shu Zhao, Yan Wang, Wenyu Di, Gangling Zhao, Maopeng Yang, and Qingyuan Zhang, “Prognostic value of survivin and EGFR protein expression in triple-negative breast cancer (TNBC) patients,” Targeted Oncology, 2013.
- Shirish M. Gadgeel, and Antoinette Wozniak, “Preclinical Rationale for PI3K/Akt/mTOR Pathway Inhibitors as Therapy for Epidermal Growth Factor Receptor Inhibitor-Resistant Non–Small-Cell Lung Cancer,” Clinical Lung Cancer, 2013.
- Cheryl A. London, “Kinase dysfunction and kinase inhibitors,” Veterinary Dermatology, vol. 24, no. 1, pp. 181–e40, 2013.
- Alexander Levitzki, “Tyrosine Kinase Inhibitors: Views of Selectivity, Sensitivity, and Clinical Performance,” Annual Review of Pharmacology and Toxicology, vol. 53, no. 1, pp. 161–185, 2013.
- Deng Pan, and Xin Lin, “Epithelial Growth Factor Receptor–Activated Nuclear Factor κB Signaling and Its Role in Epithelial Growth Factor Receptor–Associated Tumors,” The Cancer Journal, vol. 19, no. 6, pp. 461–467, 2013.
- Chuanhao Tang, Xiaoqing Liu, Xiaoyan Li, Wanfeng Guo, Jianjie Li, Haifeng Qin, Weixia Wang, Lili Qu, Juan An, and Hongjun Gao, “How to make the choice in the retreatment of EGFR-TKI for advanced NSCLC patients who benefited from prior gefitinib therapy: The original drug or switching to a second EGFR-TKI?,” Chinese Journal of Lung Cancer, vol. 16, no. 7, pp. 345–352, 2013.
- Kalliopi Domvri, Paul Zarogoulidis, Kaid Darwiche, Robert F. Browning, Qiang Li, J. Francis Turner, Ioannis Kioumis, Dionysios Spyratos, Konstantinos Porpodis, Antonis Papaiwannou, Theodora Tsiouda, Lutz Freitag, and Konstantinos Zarogoulidis, “Molecular Targeted Drugs and Biomarkers in NSCLC, the Evolving Role of Individualized Therapy,” Journal of Cancer, vol. 4, no. 9, pp. 736–754, 2013.
- Joy Tang, Rasha Salama, Shirish M. Gadgeel, Fazlul H. Sarkar, and Aamir Ahmad, “Erlotinib resistance in lung cancer: Current progress and future perspectives,” Frontiers in Pharmacology, vol. 4, 2013.
- Barbara Melosky, “Review of EGFRâ€‰TKIs in Metastatic NSCLC, Including Ongoing Trials,” Frontiers in Oncology, vol. 4, 2014.
- Cheryl A. London, “Small Molecule Inhibitors in Veterinary Oncology Practice,” Veterinary Clinics of North America-Small Animal Practice, vol. 44, no. 5, pp. 893–+, 2014.
- Diana Schveigert, Saulius Cicenas, Jaroslav Bublevic, Renatas Askinis, Virginijus Sapoka, and Janina Didziapetriene, “The role of genetic and other biomarkers in NSCLC prognosis,” Central European Journal of Medicine, vol. 9, no. 3, pp. 382–390, 2014.
- Peter Ballard, Helen C. Swaisland, Michael D. Malone, Sunil Sarda, Serban Ghiorghiu, and Darren Wilbraham, “Metabolic disposition of AZD8931, an oral equipotent inhibitor of EGFR, HER2 and HER3 signalling, in rat, dog and man,” Xenobiotica, pp. 1–16, 2014.
- Pushpendra Singh, and Felix Bast, “In silico molecular docking study of natural compounds on wild and mutated epidermal growth factor receptor,” Medicinal Chemistry Research, 2014.
- Takayasu Kurata, Junji Tsurutani, Yasuhito Fujisaka, Wataru Okamoto, Hidetoshi Hayashi, Hisato Kawakami, Eisei Shin, Nobuya Hayashi, and Kazuhiko Nakagawa, “Inhibition of EGFR, HER2 and HER3 signaling with AZD8931 alone and in combination with paclitaxel: Phase I study in Japanese patients with advanced solid malignancies and advanced breast cancer,” Investigational New Drugs, 2014.
- Julia Petschnigg, Bella Groisman, Max Kotlyar, Mikko Taipale, Yong Zheng, Christoph F Kurat, Azin Sayad, J Rafael Sierra, Mojca Mattiazzi Usaj, Jamie Snider, Alex Nachman, Irina Krykbaeva, Ming-Sound Tsao, Jason Moffat, Tony Pawson, Susan Lindquist, Igor Jurisica, and Igor Stagljar, “The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells,” Nature Methods, 2014.
- Jijun Hao, Rachel Lee, Andy Chang, Jeffery Fan, Chantelle Labib, Cyrus Parsa, Robert Orlando, Bradley Andresen, and Ying Huang, “DMH1, a Small Molecule Inhibitor of BMP Type I Receptors, Suppresses Growth and Invasion of Lung Cancer,” Plos One, vol. 9, no. 3, 2014.
- Zhangjian Huang, Yisheng Lai, Sixun Peng, Yihua Zhang, Chun Han, Ledong Wan, Hongbin Ji, and Ke Ding, “Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors,” European Journal of Medicinal Chemistry, 2014.
- Anna R Kwilas, Andressa Ardiani, Renee N Donahue, Dana T Aftab, and James W Hodge, “Dual effects of a targeted small-molecule inhibitor (cabozantinib) on immune-mediated killing of tumor cells and immune tumor microenvironment permissiveness when combined with a cancer vaccine,” Journal of Translational Medicine, vol. 12, no. 1, 2014.
- Jin‑An Ma, Chunhong Hu, Wenjuan Li, Jing Ren, Fangwenï¿½ Zou, Dongai Zhou, Wen Zou, Yajun Wei, and Ying Zhou, “Downregulation of c-Met expression does not enhance the sensitivity of gastric cancer cell line MKN-45 to gefitinib,” Molecular Medicine Reports, 2014.
- Chang Gong Lee, Susan McCarthy, Mike Gruidl, Cindy Timme, and Timothy J. Yeatman, “MicroRNA-147 Induces a Mesenchymal-To-Epithelial Transition (MET) and Reverses EGFR Inhibitor Resistance,” Plos One, vol. 9, no. 1, 2014.
- Cristina Pérez-Ramírez, Marisa Cañadas-Garre, Miguel Ángel Molina, María José Faus-Dáder, and Miguel Ángel Calleja-Hernández, “MET/HGF targeted drugs as potential therapeutic strategies in non-small cell lung cancer,” Pharmacological Research, 2015.
- Mazen Zaarour, Chanudi Weerasinghe, Bassel Nazha, Samer Hassan, and Jean-Paul Atallah, “Epidermal growth factor receptor tyrosine kinase inhibitors in elderly patients with non-small cell lung cancer,” Expert Review of Anticancer Therapy, pp. 1–10, 2015.
- E Pazarentzos, P Giannikopoulos, G Hrustanovic, J St John, V R Olivas, M A Gubens, R Balassanian, J Weissman, W Polkinghorn, and T G Bivona, “Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3CβD1067V kinase domain mutation,” Oncogene, 2015.
- Mian Xie, Jianxing He, Chaosheng He, and Shenhai Wei, “γ Secretase Inhibitor BMS-708163 Reverses Resistance to EGFR Inhibitor via the PI3K/Akt Pathway in Lung Cancer,” Journal of Cellular Biochemistry, vol. 116, no. 6, pp. 1019–1027, 2015.
- Miguel Ángel Calleja-Hernández, Cristina Pérez-Ramírez, Marisa Cañadas-Garre, Enrique Jiménez-Varo, and María José Faus-Dáder, “MET: a new promising biomarker in non-small-cell lung carcinoma,” Pharmacogenomics, vol. 16, no. 6, pp. 631–647, 2015.
- Chia-Feng Tsai, Yi-Ting Wang, Hsin-Yung Yen, Chih-Chiang Tsou, Wei-Chi Ku, Pei-Yi Lin, Hsuan-Yu Chen, Alexey I. Nesvizhskii, Yasushi Ishihama, and Yu-Ju Chen, “Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics,” Nature Communications, vol. 6, pp. 6622, 2015.
- Lichun Ma, Debby D Wang, Yiqing Huang, Hong Yan, Maria P Wong, and Victor HF Lee, “EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib,” BMC Bioinformatics, vol. 16, no. 1, 2015.
- Jasmine G. Lee, and Reen Wu, “Erlotinib-Cisplatin Combination Inhibits Growth and Angiogenesis through c-MYC and HIF-1α in EGFR-Mutated Lung Cancer In Vitro and In Vivo,” Neoplasia, vol. 17, no. 2, pp. 190–200, 2015.
- Feng-Che Kuan, Liang-Tseng Kuo, Min-Chi Chen, Cheng-Ta Yang, Chung-Sheng Shi, David Teng, and Kuan-Der Lee, “Overall survival benefits of first-line EGFR tyrosine kinase inhibitors in EGFR-mutated non-small-cell lung cancers: a systematic review and meta-anal,” British Journal Of Cancer, vol. 113, no. 10, pp. 1519–1528, 2015.
- Salvatore Lopez, Emiliano Cocco, Jonathan Black, Stefania Bellone, Elena Bonazzoli, Federica Predolini, Francesca Ferrari, Carlton L. Schwab, Diana P. English, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Corrado Terranova, Roberto Angioli, and Alessandro D. Santin, “Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo,” Molecular Cancer Therapeutics, vol. 14, no. 11, pp. 2519–2526, 2015.
- Raul Iglesias, and Piyush Koria, “Leveraging growth factor induced macropinocytosis for targeted treatment of lung cancer,” Medical Oncology, vol. 32, no. 12, 2015.
- Daixing Zhong, Yi Ru, Qinhao Wang, Jing Zhang, Jian Zhang, Junxia Wei, Jin Wu, Libo Yao, Xiaofei Li, and Xia Li, “Chimeric ubiquitin ligases inhibit non-small cell lung cancer via negative modulation of EGFR signaling,” Cancer Letters, 2015.
- Xiaochun Wang, Kathleen M. Batty, Philip J. Crowe, David Goldstein, and Jia-Lin Yang, “The Potential of panHER Inhibition in Cancer,” Frontiers in Oncology, vol. 5, 2015.
- Mustafa Kemal Kilic, Yakup Yesilkaya, Kadriye Tezcan, Nese Cinar, Safak Akin, Jale Karakaya, Deniz Akata, Aydan Usman, and Alper Gurlek, “
The association between thyroid volume,
l-thyroxine therapy and hepatocyte growth factor levels among patients with euthyroid and hypothyroid goitrous and non-goitrous Hashimoto’s thyroiditis versus healthy subjects ,” Endocrine Research, pp. 1–5, 2016.