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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 167395, 6 pages
Research Article

CTLA-4 Gene Polymorphism and the Risk of Systemic Lupus Erythematosus in the Chinese Population

1Renmin Hospital of Wuhan University, Wuhan 430060, China
2Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Received 14 April 2011; Revised 25 May 2011; Accepted 9 June 2011

Academic Editor: Nathan A. Ellis

Copyright © 2011 Ahmad Taha Khalaf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Several variants of CTLA-4 have been reported to be associated with susceptibility systemic lupus erythematosus (SLE); however, findings have been inconsistent across different populations. Using a case-control study design, we have investigated the role of CTLA-4 polymorphism at positions −1661 and −1722 on SLE susceptibility in our Chinese SLE population in central China's Hubei province. Samples were collected from 148 SLE patients and 170 healthy controls. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotypes of the two sites. Statistically significant difference was observed in genotypes for −1722, but not for −1661. The frequency of the T allele on the −1722 SNP was significantly increased in SLE patients: 57.8% versus 40.6% in controls ( 𝑃 < 0 . 0 0 1 , OR = 2.002). While the detected C allele frequency in the controls was significantly elevated in comparison to that in the SLE patients (59.4% versus 42.2%). On the contrary, no association was found between SLE and CTLA-4 polymorphism at position −1661.