Research Article
CTLA-4 Gene Polymorphism and the Risk of Systemic Lupus Erythematosus in the Chinese Population
Table 2
Genotypic distribution and allelic frequencies of −1661 CTLA-4 polymorphisms in Chinese SLE patients and healthy controls.
| | Promoter −1661 | SLE
| Controls
| | -value | OR (95% CI) |
| | Genotype frequency | | | | | | | AA | 59 (39.9%) | 63 (37.1%) | 0.263 | 0.608 | 1.126 (0.716–1.771) | | AG | 67 (45.2%) | 76 (44.7%) | 0.010 | 0.920 | 1.132 (0.730–1.755) | | GG | 22 (14.9%) | 31 (18.2%) | 0.647 | 0.421 | 0.783 (0.431–1.423) | | Allele frequency | | | | | | | A | 185 (62.5%) | 202 (59.4%) | 0.633 | 0.426 | 1.139 (0.827–1.568) | | G | 111 (37.5%) | 138 (40.6%) | | | | | Phenotype | | | | | | | A | 126 (85.1%) | 139 (81.8%) | 0.207 | 0.649 | 1.090 (0.752–1.578) | | G | 89 (60.1%) | 107 (62.9%) | | | |
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Abbreviations: CTLA-4 = cytotoxic T-lymphocyte antigen 4; SLE = systemic lupus erythematosus; OR = odds ratios; 95% CI = 95% confidence interval.
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