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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 174615, 11 pages
http://dx.doi.org/10.1155/2011/174615
Methodology Report

Bioactivity Determination of Native and Variant Forms of Therapeutic Interferons

1Biologics and Genetic Therapies Directorate, Health Canada, Tunney's Pasture, Ottawa, ON, Canada K1A 0K9
2National Institute for the Control of Pharmaceutical and Biological Products, Beijing, 100810, China
3Department of Experimental Medicine, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada H3A 2T5
4National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada R3E 3R2
5Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada K1H 8M5

Received 15 November 2010; Accepted 14 January 2011

Academic Editor: Andrei Surguchov

Copyright © 2011 Louise Larocque et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Grant Frahm, Xuguang Li, Yves Durocher, and Mary Alice Hefford, “O-Linked Glycosylation Leads to Decreased Thermal Stability of Interferon A lpha 2b as Measured by Two Orthogonal Techniques,” Pharmaceutical Research, vol. 28, no. 7, pp. 1661–1667, 2011. View at Publisher · View at Google Scholar
  • Marsha S. Russell, Changgui Li, Louise Larocque, Junzhi Wang, Aaron Farnsworth, Runtao He, and Xuguang Li, “Rapid and accurate determination of the potency of varicella vaccine by quantitative polymerase chain reaction,” Vaccine, vol. 29, no. 47, pp. 8490–8495, 2011. View at Publisher · View at Google Scholar
  • Marianne Berger Rentsch, and Gert Zimmer, “A vesicular stomatitis virus replicon-based bioassay for the rapid and sensitive determination of multi-species type I interferon,” PLoS ONE, vol. 6, no. 10, 2011. View at Publisher · View at Google Scholar
  • John K. Mark, Sophie Dionne, Terry D. Cyr, Sylvie Boucher, Michel Girard, and Mary Alice Hefford, “Utility of standard pharmacopeial and nonpharmacopeial methods in distinguishing folded, unfolded, and process variant forms of interferon α-2,” Journal of Pharmaceutical Sciences, vol. 101, no. 10, pp. 3672–3686, 2012. View at Publisher · View at Google Scholar
  • Lei Yu, Chunming Rao, Xinchang Shi, Yonghong Li, Kai Gao, Xuguang Li, and Junzhi Wang, “A Novel Bioassay for the Activity Determination of Therapeutic Human Brain Natriuretic Peptide (BNP),” Plos One, vol. 7, no. 11, 2012. View at Publisher · View at Google Scholar
  • Riccardo Torosantucci, Christian Schöneich, and Wim Jiskoot, “Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences,” Pharmaceutical Research, 2013. View at Publisher · View at Google Scholar
  • Emily Voigt, Bahar Inankur, Ashley Baltes, and John Yin, “A quantitative infection assay for human type I, II, and III interferon antiviral activities,” Virology Journal, vol. 10, 2013. View at Publisher · View at Google Scholar