Research Article
Direct Determination of ECD in ECD Kit: A Solid Sample Quantitation Method for Active Pharmaceutical Ingredient in Drug Product
Table 1
Optimized parameters of elemental analyzer for quantitation of ECD in ECD Kit.
| Parameters | |
| Operation mode | CHNS | Combustion temperature (°C) | 1150 | Reduction temperature (°C) | 900 | Flush gas/time (sec) | He/10 | O2 dosing time (sec) | 120 | Column standby temperature (°C) | | CO2 | Ambient temperature | H2O | Ambient temperature | SO2 | 140 | Column desorption temperature (°C) | | CO2 | 240 | H2O | 150 | SO2 | 220 | Carrier gas/Flow rate (mL/min)(1) | He/230 | Flow rate of O2 (mL/min) | 15 | Flow rate of O2 during combustion (mL/min) | 30–35 |
|
|
(1)Same as the mass flow control (MFC) TCD flowing gas and flow rate.
|