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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 197636, 11 pages
http://dx.doi.org/10.1155/2011/197636
Review Article

Biology of Obesity: Lessons from Animal Models of Obesity

Division of Diabetes & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan

Received 14 September 2010; Accepted 13 December 2010

Academic Editor: Monica Fedele

Copyright © 2011 Keizo Kanasaki and Daisuke Koya. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity is an epidemic problem in the world and is associated with several health problems, including diabetes, cardiovascular disease, respiratory failure, muscle weakness, and cancer. The precise molecular mechanisms by which obesity induces these health problems are not yet clear. To better understand the pathomechanisms of human disease, good animal models are essential. In this paper, we will analyze animal models of obesity and their use in the research of obesity-associated human health conditions and diseases such as diabetes, cancer, and obstructive sleep apnea syndrome.