Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia-Inducible Factors

Table 1

Histone deacetylases: Classification and characteristics.

Classes		HDACs	Localization	Features
Class I	Ia	HDAC 1, 2	Nucleus	Related to yeast RPD3 deacetylase Zinc dependent [57]
	Ib	HDAC 3	Nucleus & cytoplasm
	Ic	HDAC 8	Nucleus
Class II	IIa	HDAC 4, 5, 7, 9	Nucleus/cytoplasm [58]	Related to yeast HdaI Zinc-dependent [23, 24]
	IIb	HDAC6	Cytoplasm
		HDAC10	Nucleus/cytoplasm [59, 60]
Class III	Sirtuins (Sirt1-7)		Nucleus, cytoplasm & mitochondria	Related to the Sir2 NAD+-dependent [25]
Class IV	HDAC 11		Nucleus & cytoplasm	Features of both classes I and II [61], Zinc independent