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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 209787, 9 pages
http://dx.doi.org/10.1155/2011/209787
Research Article

Diagnostic Value of I-131 NP-59 SPECT/CT Scintigraphy in Patients with Subclinical or Atypical Features of Primary Aldosteronism

1Division of Nephrology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, and School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
2Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, and School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
3Department of General Surgery, Buddhist Dalin Tzu Chi General Hospital, Chiayi 622, Taiwan
4Department of Nuclear Medicine, Chang Bing Show Chwan Memorial Hospital, Changhua County 505, Taiwan
5Department of Pathology, Buddhist Dalin Tzu Chi General Hospital, Chiayi 622, Taiwan
6Department of Medical Imaging, Buddhist Dalin Tzu Chi General Hospital, Chiayi 622, Taiwan
7Department of Nuclear Medicine, Buddhist Dalin Tzu Chi General Hospital, and School of Medicine, Tzu Chi University, Hualien 97004, Taiwan

Received 30 December 2010; Accepted 15 February 2011

Academic Editor: David J. Yang

Copyright © 2011 Yi-Chun Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Accumulating evidence has shown the adverse effect of long-term hyperaldosteronism on cardiovascular morbidity that is independent of blood pressure. However, the diagnosis of primary aldosteronism (PA) remains a challenge for patients who present with subtle or atypical features or have chronic kidney disease (CKD). SPECT/CT has proven valuable in the diagnosis of a number of conditions. The aim of this study was to determine the usefulness of I-131 NP-59 SPECT/CT in patients with atypical presentations of PA and in those with CKD. The records of 15 patients with PA were retrospectively analyzed. NP-59 SPECT/CT was able to identify adrenal lesion(s) in CKD patients with suspected PA. Patients using NP-59 SPECT/CT imaging, compared with those not performing this procedure, significantly featured nearly normal serum potassium levels, normal aldosterone-renin ratio, and smaller adrenal size on CT and pathological examination and tended to feature stage 1 hypertension and non-suppressed plasma renin activity. These findings show that noninvasive NP-59 SPECT/CT is a useful tool for diagnosis in patients with subclinical or atypical features of PA and those with CKD.