Diagnostic Value of I-131 NP-59 SPECT/CT Scintigraphy in Patients with Subclinical or Atypical Features of Primary Aldosteronism

Table 1

Demographic and clinical data of study subjects.

Patient	Age (y)	Gender	BP (mm Hg) at admission		HTN* stage	Chief complaint	Laboratory tests					Confirmatory tests
			SBP	DBP			Serum K (mEq/L)	PAC^# (ng/dL)	PRA^# (ng/mL/h)	ARR	TTKG	Test	Result
Control group (n = 9)
1	50	F	230	130	2	HTN	2.2	60.08	0.13	462	—	Captopril	Positive
2	34	F	186	105	2	Weakness	1.6	45.80	0.13	352	4.5	Saline loading	Positive
3	58	F	220	120	2	HTN	2.69	29.28	0.13	225	—	Captopril	Positive
4	32	F	182	121	2	HTN	2.87	40.00	1.71	23	—	—	—
5	71	F	146	94	1	Weakness	2.61	32.10	0.05	642	6.2	—	—
6	59	M	152	71	1	HTN	3.49	25.55	0.45	57	—	Saline loading	Positive
7	60	F	160	90	2	Weakness	1.74	110.70	0.18	615	11.9	—	—
8	72	M	180	117	2	Weakness	1.96	31.80	0.06	122	—	—	—
9	56	F	154	83	1	Weakness	2.76	21.70	0.53	41	6.1	—	—
SPECT/CT group (n = 6)
10	55	F	140	90	1	Accidentally palpable Irregular pulse	3.24	31.9	2.52	13	8.8	Saline loading Captopril	Negative
11	48	F	145	80	1	HTN	4.01	26.8	0.06	447	—	Saline loading Captopril	Negative
12^†	57	M	170	100	2	HTN	2.79	37.2	0.32	116	72.1 mEq/d^!	Saline loading	Negative
13	56	M	144	90	1	—	4.14	25.3	1.31	12	—	—	—
14	39	M	206	115	2	HTN	2.2	27.5	1.68	16	8.2	—	—
15^†	27	F	150	88	1	HTN	4.32	29.3	1.62	18	—	Captopril	Negative

Abbreviations: SBP: systolic blood pressure; DBP: diastolic blood pressure; HTN: hypertension; S/S: symptom/sign; K: potassium; PAC: plasma aldosterone concentration; PRA: plasma renin activity; ARR: aldosterone-renin ratio; TTKG: transtubular potassium gradient; F: female; M: male.
^#Normal range of PAC, PRA, and serum K is 3.7–24 ng/dL, 0.15–2.33 ng/mL/h, and 3.5 to 5.0 mEq/L, respectively.
*HTN stage according to JNC 7 report.
^† Patients 12 and 15 had stages 3 and 4 chronic kidney disease with serum creatinine level of 2.2 mg/dL (eGFR 32.9 mL/min/1.73 m²) and 2.5 mg/dL (eGFR 24.6 mL/min/1.73 m²), respectively.
^!24-hour urine excretion of potassium.