The Dystrophin-Glycoprotein Complex in the Prevention of Muscle Damage

Figure 2

The dystrophin-glycoprotein complex may participate in laminin-dependent signaling in skeletal muscle. Interactions shown in blue indicate interactions that have been shown to be increased when laminin is bound to dystroglycan. Interactions in pink indicate those that have been shown to be increased following a muscle contraction protocol. Since the phosphorylation of β-dystroglycan can bind a number of other SH2-domain containing proteins and can also interact with Grb2, it may participate in additional signal transduction cascades that have not yet been identified. It is important to remember that in many cases, these interactions have been studied in cell culture systems and the relevance of these interactions in muscle in vivo has not been extensively studied.