Myelodysplastic Syndrome and Histone Deacetylase Inhibitors: “To Be or Not to Be Acetylated”?

Figure 1

Pathophysiological mechanisms involved in MDS and points of action for possible therapy approaches. Abbreviations: AML: acute myeloid leukaemia; GCSF: granulocyte colony-stimulating factor; GSH: glutathione; MAPK: mitogen-activated protein kinase; MDS: myelodysplastic syndrome; PDGFR: platelet-derived growth factor receptor; RA: retinoic acid; SCT: stem cell transplantation; TNF: tumour necrosis factor; VEGF: vascular-endothelial growth factor.