Equal Force Recovery in Dysferlin-Deficient and Wild-Type Muscles Following Saponin Exposure

Table 1

Tetanic forces (kN/m²) of WT and dysferlin-null EDL muscles at room temperature before and after saponin exposure.

	Initial	10 min	20 min	30 min	40 min	50 min	60 min
WT, N = 5	273.6 ± 4.9	41.9 ± 6.1	75.7 ± 10.2; ^(a)𝑃 = 0.002	101.7 ± 11.5; P = 0.0007	114.5 ± 11.8; P = 0.18	117.1 ± 11.8; P = 0.18	117.0 ± 11.1; P = 0.92
KO, N = 5	251.3 ± 13.5	47.5 ± 15.0	77.4 ± 14.8; P = 0.016	97.1 ± 18.3; P = 0.042	102.1 ± 19.0; P = 0.048	102.2 ± 18.7; P = 0.81	102.4 ± 18.6; P = 0.83
^(b)𝑃	0.09	0.74	0.93	0.84	0.59	0.52	0.52

Note: (a) the P values under the force data are the paired t-test of the forces at the specific time point compared to that measured at the prior time point (e.g., WT force at 20 min compared to that at 10 min); (b) the P values in the last row are the unpaired t-test of forces between WT and dysferlin-null groups at each time point.