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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 238409, 11 pages
Motor-Evoked Potential Confirmation of Functional Improvement by Transplanted Bone Marrow Mesenchymal Stem Cell in the Ischemic Rat Brain
1Institute of Catholic Integrative Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon 403-720, Republic of Korea
2Department of Neurosurgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, 65-1 Kumoh-dong Uijeongbu, Gyeonggi 480-130, Republic of Korea
3Department of Biochemistry, The Catholic University of Korea College of Medicine, Seoul 137-701, Republic of Korea
Received 12 January 2011; Revised 21 March 2011; Accepted 25 March 2011
Academic Editor: Thomas Van Groen
Copyright © 2011 Dong-Kyu Jang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. Arvidsson, T. Collin, D. Kirik, Z. Kokaia, and O. Lindvall, “Neuronal replacement from endogenous precursors in the adult brain after stroke,” Nature Medicine, vol. 8, no. 9, pp. 963–970, 2002.
- N. Pavlichenko, I. Sokolova, S. Vijde et al., “Mesenchymal stem cells transplantation could be beneficial for treatment of experimental ischemic stroke in rats,” Brain Research, vol. 1233, pp. 203–213, 2008.
- E. Keimpema, M. R. Fokkens, Z. Nagy et al., “Early transient presence of implanted bone marrow stem cells reduces lesion size after cerebral ischaemia in adult rats,” Neuropathology and Applied Neurobiology, vol. 35, no. 1, pp. 89–102, 2009.
- S. W. Yoo, S. S. Kim, S. Y. Lee et al., “Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model,” Experimental and Molecular Medicine, vol. 40, no. 4, pp. 387–397, 2008.
- L. H. Shen, Y. Li, J. Chen et al., “Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke,” Neuroscience, vol. 137, no. 2, pp. 393–399, 2006.
- J. Wu, Z. Sun, H. S. Sun et al., “Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats,” Cell Transplantation, vol. 16, no. 10, pp. 993–1005, 2008.
- E. M. Andrews, S. Y. Tsai, S. C. Johnson et al., “Human adult bone marrow-derived somatic cell therapy results in functional recovery and axonal plasticity following stroke in the rat,” Experimental Neurology, vol. 211, no. 2, pp. 588–592, 2008.
- S. Iihoshi, O. Honmou, K. Houkin, K. Hashi, and J. D. Kocsis, “A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats,” Brain Research, vol. 1007, no. 1-2, pp. 1–9, 2004.
- S. M. Cartmell, L. Gelgor, and D. Mitchell, “A revised rotarod procedure for measuring the effect of antinociceptive drugs on motor function in the rat,” Journal of Pharmacological Methods, vol. 26, no. 2, pp. 149–159, 1991.
- A. Nogradi and G. Vrbova, “Improved motor function of denervated rat hindlimb muscles induced by embryonic spinal cord grafts,” European Journal of Neuroscience, vol. 8, no. 10, pp. 2198–2203, 1996.
- H. Westergren, M. Farooque, Y. Olsson, and A. Holtz, “Motor function changes in the rat following severe spinal cord injury. Does treatment with moderate systemic hypothermia improve functional outcome?” Acta Neurochirurgica, vol. 142, no. 5, pp. 567–573, 2000.
- S. R. Cho, Y. R. Kim, H. S. Kang et al., “Functional recovery after the transplantation of neurally differentiated mesenchymal stem cells derived from bone barrow in a rat model of spinal cord injury,” Cell Transplantation, vol. 18, no. 12, pp. 1359–1368, 2009.
- M. Ohta, Y. Suzuki, T. Noda et al., “Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation,” Experimental Neurology, vol. 187, no. 2, pp. 266–278, 2004.
- M. Zurita and J. Vaquero, “Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation,” NeuroReport, vol. 15, no. 7, pp. 1105–1108, 2004.
- H. Bolay, Y. Gürsoy-Özdemir, I. Ünal, and T. Dalkara, “Altered mechanisms of motor-evoked potential generation after transient focal cerebral ischemia in the rat: implications for transcranial magnetic stimulation,” Brain Research, vol. 873, no. 1, pp. 26–33, 2000.
- R. D. Linden, Y. P. Zhang, D. A. Burke, M. A. Hunt, J. E. Harpring, and C. B. Shields, “Magnetic motor evoked potential monitoring in the rat,” Journal of Neurosurgery, vol. 91, supplement 2, pp. 205–210, 1999.
- G. C. Teskey, C. Flynn, C. D. Goertzen, M. H. Monfils, and N. A. Young, “Cortical stimulation improves skilled forelimb use following a focal ischemic infarct in the rat,” Neurological Research, vol. 25, no. 8, pp. 794–800, 2003.
- M. G. Schlag, R. Hopf, and H. Redl, “Serial recording of sensory, corticomotor, and brainstem-derived motor evoked potentials in the rat,” Somatosensory and Motor Research, vol. 18, no. 2, pp. 106–116, 2001.
- P. E. Konrad and W. A. Tacker, “Suprathreshold brain stimulation activates non-corticospinal motor evoked potentials in cats,” Brain Research, vol. 522, no. 1, pp. 14–29, 1990.
- H. Bolay and T. Dalkara, “Mechanisms of motor dysfunction after transient MCA occlusion: persistent transmission failure in cortical synapses is a major determinant,” Stroke, vol. 29, no. 9, pp. 1988–1993, 1998.
- E. Z. Longa, P. R. Weinstein, S. Carlson, and R. Cummins, “Reversible middle cerebral artery occlusion without craniectomy in rats,” Stroke, vol. 20, no. 1, pp. 84–91, 1989.
- K. Sakatani, H. Iizuka, and W. Young, “Somatosensory evoked potentials in rat cerebral cortex before and after middle cerebral artery occlusion,” Stroke, vol. 21, no. 1, pp. 124–132, 1990.
- K. J. Sanderson, W. Welker, and G. M. Shambes, “Reevaluation of motor cortex and of sensorimotor overlap in cerebral cortex of albino rats,” Brain Research, vol. 292, no. 2, pp. 251–260, 1984.
- S. Zandieh, R. Hopf, H. Redl, and M. G. Schlag, “The effect of ketamine/xylazine anesthesia on sensory and motor evoked potentials in the rat,” Spinal Cord, vol. 41, no. 1, pp. 16–22, 2003.
- H. P. Grunert, O. Landt, M. Zirpel-Giesebrecht et al., “Trp59 to Tyr substitution enhances the catalytic activity of RNase T1 and of the Tyr to Trp variants in positions 24, 42 and 45,” Protein Engineering, vol. 6, no. 7, pp. 739–744, 1993.
- J. A. Gruner and A. K. Yee, “4-aminopyridine enhances motor evoked potentials following graded spinal cord compression injury in rats,” Brain Research, vol. 816, no. 2, pp. 446–456, 1999.
- T. Kamida, M. Fujiki, S. Hori, and M. Isono, “Conduction pathways of motor evoked potentials following transcranial magnetic stimulation: a rodent study using a 'figure-8' coil,” Muscle and Nerve, vol. 21, no. 6, pp. 722–731, 1998.
- T. Sun, M. G. Schlag, R. Hopf, Q. Shen, and H. Redl, “Brainstem-evoked muscle potentials: their prognostic value in experimental spinal cord injury in the rat,” Somatosensory and Motor Research, vol. 17, no. 4, pp. 317–324, 2000.
- V. E. Amassian, M. Stewart, G. J. Quirk, and J. L. Rosenthal, “Physiological basis of motor effects of a transient stimulus to cerebral cortex,” Neurosurgery, vol. 20, no. 1, pp. 74–93, 1987.
- J. Adamson, R. A. Zappulla, A. Fraser, J. Ryder, and L. I. Malis, “Effects of selective spinal cord lesions on the spinal motor evoked potential (MEP) in the rat,” Electroencephalography and Clinical Neurophysiology, vol. 74, no. 6, pp. 469–480, 1989.
- W. J. Z'Graggen, G. A. S. Metz, G. L. Kartje, M. Thallmair, and M. E. Schwab, “Functional recovery and enhanced corticofugal plasticity after unilateral pyramidal tract lesion and blockade of myelin-associated neurite growth inhibitors in adult rats,” Journal of Neuroscience, vol. 18, no. 12, pp. 4744–4757, 1998.
- M. G. Fehlings, R. J. Hurlbert, and C. H. Tator, “The electrophysiological assessment of the pyramidal and non-pyramidal tracts of the spinal cord of rats,” Electroencephalography and Clinical Neurophysiology. Supplement, vol. 43, pp. 287–296, 1991.
- E. Kosar, Y. Fujito, F. Murakami, and N. Tsukahara, “Morphological and electrophysiological study of sprouting of corticorubral fibers after lesions of the contralateral cerebrum in kitten,” Brain Research, vol. 347, no. 2, pp. 217–224, 1985.
- T. Mittmann, M. Qü, K. Zilles, and H. J. Luhmann, “Long-term cellular dysfunction after focal cerebral ischemia: in vitro analyses,” Neuroscience, vol. 85, no. 1, pp. 15–27, 1998.