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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 245728, 9 pages
Research Article

Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection

1Department of Education and Research, Taichung Veterans General Hospital, 160, Section 3 Taichungkang Road, Taichung 40705, Taiwan
2Department of Veterinary Medicine, National Chung-Hsing University, Taichung 40227, Taiwan
3Division of Critical Care and Respiratory Therapy, Taichung Veterans General Hospital, Taichung 40705, Taiwan
4Department of Animal Science, National Chung-Hsing University, Taichung 40227, Taiwan

Received 24 June 2010; Revised 11 August 2010; Accepted 7 September 2010

Academic Editor: Monica Fedele

Copyright © 2011 Ching-Chang Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bronchiolitis obliterans organizing pneumonia (BOOP) is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS), typical BOOP lesions were revealed. All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2) was identified. They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs), extracellular collagen matrix (ECM) deposition, and fragmentation of elastic fibers. MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion. These molecules colocalized with the active MFBs. Both gelatinase activity and intercellular level of active MFBs were significantly increased ( 𝑃 < . 0 5 ). Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection. Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.